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[X-plor] Please attend a workshop on Measurement and Interpretation of Diffuse Scattering in X-Ray Diffraction for Macromolecular Crystallography

Robert Sweet via x-plor%40net.bio.net (by sweet from bnl.gov)
Wed Mar 8 09:38:58 EST 2017


Driven by recent advances in this field we will hold a workshop to discuss 
it. The workshop will be on Monday, May 15, 2017 at Brookhaven Nat'l 
Laboratory, and will be affiliated with the 2017 Users' Meeting for 
NSLS-II and the Center for Functional Nanomaterials.

The current draft agenda is on-line here: 
http://usersmeeting.ps.bnl.gov/workshops/workshop.aspx?year=2017&id=136

Registration for the Workshop and Users' Meeting is here: 
http://usersmeeting.ps.bnl.gov/registration/?year=2017

A description of the workshop is below.

The Organizers: Robert Sweet (NSLS-II, BNL), Michael Wall (LANL), Nozomi 
Ando (Princeton University), James S. Fraser (University of California, 
San Francisco), George N. Phillips, Jr. (Rice University)

For answers to questions, please contact Wall: mewall from lanl.gov or Sweet: 
sweet from bnl.gov

Description:
X-ray diffraction from macromolecular crystals includes both sharply 
peaked Bragg reflections and diffuse intensity between the peaks.  The 
information in Bragg scattering reflects the mean electron density in the 
unit cells of the crystal.  The diffuse scattering arises from 
correlations in the variations of electron density that may occur from one 
unit cell to another, and therefore contains information about collective 
motions in proteins.

A major focus of the workshop will be to provide a roadmap to the 
acquisition of reliable data by surveying measurement methods and 
discussing the increase in measurement accuracy enabled by improved 
detectors, experimental methods, and data integration.

Missing from recent results is real information about the behavior of the 
molecules being studied that would guide the thinking of biochemists and 
biologists.  To discuss these and their relative merits will be a second 
major focus of the workshop.

The charge to this workshop will be to provide a roadmap to efforts that 
will provide the biological understanding we believe is hidden in the 
data.

=========================================================================
         Robert M. Sweet                   E-Dress:  sweet from bnl.gov
         Deputy Director, LSBR: The Life Science and         ^ (that's L
           Biomedical Technology Research Center at NSLS-II       not 1)
         Photon Sciences and Biology Dept
         Office and mail, Bldg 745, a.k.a. LOB-5
         Brookhaven Nat'l Lab.             Phones:
         Upton, NY  11973                  631 344 3401  (Office)
         U.S.A.                            631 344 2741  (Facsimile)
=========================================================================



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