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[Virology] RCDI/eRCDI web-server for codon usage deoptimization

Pere Puigbo via virology%40net.bio.net (by ppuigbo from urv.cat)
Thu Apr 1 09:33:35 EST 2010

The RCDI server is a web-application that calculates the Relative Codon
Deoptimization Index (RCDI) and an expected value of the RCDI for a set of
query sequences by generating random sequences with similar G+C content and
amino acid composition to the input. The purpose of the server is to help in
the analysis of host-virus phylogenetic relationships or to infer the
potential host range of a virus and its replication strategy, as well as in
experimental virology to ease the step of gene design for heterologous
protein expression.

RCDI/E-RCDI is and update of the server CAIcal (
http://genomes.urv.cat/CAIcal). This server is freely accessible at

For more details see Puigbo et al. (2010) BMC Reasearch Notes, 3:87.

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