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Influenza Neuraminidase J Mone'

Jay Mone' jmone at marauder.millersv.edu
Fri May 30 11:11:44 EST 1997


Some answers to your questions:
1.  Neuraminidase appears to be important in the release of virus from 
infected cells, but the precise function in this context is unclear.  It 
is known that influenza viruses which lack NA form particles containing 
neuraminic acid, which forms large aggregates and result in lower virus 
yields.

2.  The specificity of the viral NA is terminal scialic acid residues 
adjacent to galactose of galactosamine.  These biochemical moieties also 
are involved in binding of virus to target cells via the hemagglutinin.  
If virus is not internalized following binding of virus, the NA can 
cleave the receptor and elute the virus from the cell.

3.  Influenza remains localized to upper respiratory tract and nevers 
establishes viremia.

Jay Mone'
Millersville University
Millersville, PA, USA





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