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Inactivated SALK vaccine

A.J.Cann nna at leicester.ac.uk
Tue Jan 28 09:37:45 EST 1997


In article <5ckiqm$71i at net.bio.net>, "Gustavo Palacios"
<ustavopa at interserver.com.ar> wrote:

>D you know a way to explain why a inactivated vaccine as Salk can
>generate a inmune response that protect humans to poliomyelitis since
>1960 ?. I expect that an RNA virus as PV can mutate in a way to
>"escape" from the inmune response generated to the same antigen ? Or
>the vaccine is variated along the time as the FMDV vaccine, (that it
>is other vaccine, by the way, that must to be variated to mantain
>protection while the virus mutated in the field ? Do you know about
>some work in this specific field ?
>
>Thanks in advance and forgive for my English
>
>Gustavo Palacios
>Buenos Aires, Argentina

The three serotypes of poliovirus are essentially invariant with time,
due to the structure of the capsid. Few changes can be tolerated in
this structure, hence most mutants are not viable.

-- 
Dr Alan J. Cann  PhD, Department of Microbiology & Immunology,
University of Leicester, P.O. Box 138, Medical Sciences Building,
Unversity road, Leicester LE1 9HN, UK. Email: nna at le.ac.uk



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