Jay Evans wrote:
>> I am looking for any information (refs) on DNA binding proteins that form
> trimers in solution or when bound to DNA (or RNA). Any references or
> leads you can give me would be greatly appreciated.
>> Jay Evans
>evansj at bcc.orst.edu
The primase-helicase complex from herpes simplex virus is a trimer of
the UL5, 8, and 52 gene products. I haven't kept up with the literature
over the last few years, but here's a ref that might be useful:
Crute, J.J., Tsurumi, T., Zhu, L., Weller, S.K., Olivo, P.D., Challberg,
M.D., Mocarski, E.S., and Lehman, I.R. (1989). Herpes Simplex Virus i
Helicase-Primase: A Complex of Three Herpes Encoded Gene Products. Proc.
Natl. Acad. Sci. USA 86, 2186-2189.
Mark Challberg, Sandra Weller and Nigel Stow's labs have published on
the area since, if you want to look further.
Division of Virology
Department of Pathology
University of Cambridge