IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP

protein trimers

Giovanni Maga maga at vetbio.unizh.ch
Tue Sep 24 14:01:04 EST 1996

In article <51rvt8$ahq at net.bio.net>, evansj at ava.bcc.orst.edu (Jay Evans) wrote:

> I am looking for any information (refs) on DNA binding proteins that form
> trimers in solution or when bound to DNA (or RNA).  Any references or
> leads you can give me would be greatly appreciated.
> Jay Evans
> evansj at bcc.orst.edu

HSSB also called Replication Protein A (RP-A) molecule is a heterotrimer
(i.e. composed of three subunits). This heterotrimer binds ssDNA in a
trimeric fashion (i.e., three RP-A molecules form a stable complex on
DNA). Check the recent papers by J. Borowiec about the DNA binding
mechanism of RP-A.
You would also like to check some ref. about DnaA protein of E.Coli
mechanism of DNA binding. It forms multimers in a cooperative manner by
binding DNA. Even if not trimers, the dynamics of these complexes are very
interesting. Check papers by W. Messer.
Hope it helps. G.Maga.

More information about the Virology mailing list

Send comments to us at biosci-help [At] net.bio.net