Two postdoctoral positions are available immediately in my laboratory
at Medical College of Georgia, Augusta, GA 30912. The focus of my lab
is on two related but separated subjects: tumor suppressor protein
p53-dependent apoptosis and cell cycle regulation. By using
tetracycline inducible promoter, we generated a number of cell lines
that express inducible p53 and p21. Recently, we cloned a number of
genes that potentially mediate p53-dependent apoptosis and cell cycle
arrest. My lab is well equipped and now has one energetic postdoc and
one well-trained research assistant. The following is some of my
Chen, X., L. Ko, and C. Prives. p53 levels, functional domains and DNA
damage determine the extent of the apoptotic response of tumor cells.
Genes & Dev. In Press.
Chen, X., G. Farmer, H. Zhu, R. Prywes, and C. Prives. 1993.
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism
for transcriptional activation. Genes & Dev. 7:1837-1849.
Chen, X., J. Bargonnetti, and C. Prives. 1995. p53, through p21
(WAF1/CIP1), induces cyclin D1 synthesis. Cancer Research.
If you are interested, please e-mail your resume to
"xchen at mail.mcg.edu " or send your C.V. to Xinbin Chen, CB2803, IMMAG,
Medical College of Georgia, Augusta, GA 30912.