Since retroviruses and pararetroviruses replicate via an RNA intermediate,
the mutation frequency in the final ds DNA form is a consequence of the
fidelity of both host RNA pol II and the viral RT. However, the only
information regarding RNA pol II fidelity was from Eur. J. Biochem. a
couple of years ago and this was for enzyme isolated from wheat germ.
Anyone know if fidelity of mammalian RNA pol II has been examined recently
(journal, meeting proceedings/abstract)?
Karl the hepB guy
tyr-2 at bones.biochem.ualberta.ca