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Recombination and reassortment

Bruce Phillips bap at MED.PITT.EDU
Fri Mar 24 11:51:24 EST 1995


	There seems tobe some confusion here.  It has always been my under-
standing that reassortment is a form of recombination- certainly the outcome
is the same in all cases.  Whenever recombination requires the breaking and
rejoining (ligating) of molecules, it is relatively inefficient; hence,
the recombination rate of picornaviruses is very very low.  In contrast,
when the genes of a virus are present in different molecules to begin with,
then "recombination" can be accomplished by simply reshuffling the different
genes- and this can happen when two different strains of a virus infected
the same cells.  The classic example being antigenic shift in influenza viruses.



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