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Intergration of HIV genome into host cell?

Patrick O'Neil patrick at corona
Sat Mar 18 00:37:35 EST 1995

On 18 Mar 1995 jfrost at packet.net wrote:
> Is there any information that would indicate  exactly where 
> in the host genome does the HIV integrate it's own genetic mateerial

At this time, integration appears to be rather random with one caveat:  
integration is favored in transcriptionally active regions of the genome 
over quite regions.  Nevertheless, within the active regions integration is 
essentially random.

> Also once a cell becomes infected can another viral partical infect
> it agian.
HIV, like many viruses, demonstrates superinfection immunity, that is, an 
infected cell is generally immune to other viruses of the same strain at 
least.  An unrelated virus could still infect the cell, however.


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