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ancient viruses

Craig Marshall craigm at sanger.otago.ac.nz
Mon Mar 13 17:44:30 EST 1995


There is a region of both the human and chimpanzee chromosome, coding
for the dystrophin gene, which contains a THE-1 element which is a
retrotransposon and is probably derived from some sort of virus. THE-1
elements are widely dispersed around primate chromosomes and are also
found in galagos. Two references to this are:

McNaughton, J.C., Broom, J.E., Hill, D.F., Jones, W.A., Marshall, C.J.,
Renwick, N.M., Stockwell, P.A. & Petersen, G.B. (1993) A cluster of
transposon-like repetitive sequences in intron 7 of the human
dystrophin gene. J. Mol. Biol. 232 314­321

McNaughton, J.C.,Marshall, C.J., Broom, J.E., Hill, D.F., Jones, W.A.,
Stockwell, P.A. & Petersen, G.B. (1994) Phylogenetic relationships
among
transposon-like elements in human and primate DNA: Implications for
their
mechanism of propagation. J. Mol. Evol. 40:127-135

--
Craig Marshall    Department of Biochemistry, University of Otago
                  Dunedin, New Zealand



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