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Anyone used GEE to analyze Ab titers?

Jeffrey Johnston ilva at email.unc.edu
Sun Jul 30 19:37:36 EST 1995

I'd like to know whether anyone has had experience using the statistical 
method known as generalized estimating equations in the analysis of 
repeat viral diseases. A friend of mine is thinking of using the method  
to analyze repeat seroconversions among children exposed to Norwalk 
virus from a contaminated water source. As I understand it, the advantage 
of GEE is that one can take into account repeated exposures to the virus 
and account for previous immunity. The analytical procedure is relatively 
new and I'm looking for examples of how it's been applied, its perceived 
strengths and weaknesses, and ease of use.

I suspect this may be a topic more suitable for a statistical newsgroup 
but I thought I'd try here first in case any virologists also get into 
the analysis of disease outbreaks. 

--Jeff Johnston (ilva at email.unc.edu), UNC-Chapel Hill, Epidemiology

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