In article <enkemans-2607951617480001 at 18.104.22.168>,
enkemans at dc37a.nci.nih.gov (Steven Enkemann) writes:
> There is also a third underlying cause for the discrepency between the
> measused number of virions and the number of plaque forming units. That
> is the difficulty of initiating the infectious process itself. A virus is
> very tiny. During the course of an infection it must initiate a series of
> virally directed biochemical reactions at the same time as it usurps the
> biochemical machinery of it's host. Any biochemical reaction has a finite
> probability of failing. For a tiny virus, packaging only one or two of
> the components required to initiate an infection, this becomes a form of
> 'Russian Roulette'. If the initial reactions fail, or the components
> required for that reaction never meet because they became lost within the
> vast sea of the host, the viral infection fails.
>> Steven A. Enkemann PhD.
would you predict that bigger viruses characteristically have lower
particle/pfu ratios than very small viruses?
Kevin W. Ryan
Department of Virology & Molecular Biology
St. Jude Children's Research Hospital
Memphis, Tennessee 38101-0318, U.S.A.
phone: (901) 495-3411
fax: (901) 523-2622
Internet: ryan at mbcf.stjude.org