pk20 at cornell.edu (Peter) wrote:
>Here's a question that's been plaguing my mind for a while. What
>causes HIV and other viruses to remain lysogenic/dormant for long periods of
>time, if they indeed do so?
They don't. Read the paper(s) by David Ho et al published in Nature last year,
Ho,D. et al. Rapid turnover of plasma virions & CD4 lymphocytes in HIV-1
infection. Nature 373: 123-126 (1995).
>Apparently HIV isn't detectable for six months after infection; is this due to dormancy?
Oh yes it is (by PCR) - read the paper cited above. ANTIBODIES are not detectable for 6-8 weeks after infection.
>p.s. I'm getting mixed signals from professors concerning gene therapy. Some
> seem to imply that it has great potential as a clinical tool while others
>cast it aside as something that is stirring up a lot of dreams but will soon
>fizzle out. Should I be thinking about gearing my graduate studies towards
>gene therapy or is this foolish? Which grad schools have good active research
>in this area? I never run out of questions...
Gene therapy is not foolish, it's part of the future of medicine - but we're not quite there yet.
Dr Alan J. Cann PhD, Department of Microbiology & Immunology,
University of Leicester, P.O. Box 138, Medical Sciences Building,
University Road, Leicester LE1 9HN, UK.
Email: nna at le.ac.ukhttp://www-micro.msb.le.ac.uk/AJC/nna.html