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Idea for Ebola Vaccine

Paul Wilson wilson at cs.utexas.edu
Wed Aug 2 18:50:48 EST 1995

In article <3v5ual$egh at cisunix1.dfci.harvard.edu>,
Ian A. York <york at mbcrr.dfci.harvard.edu> wrote:
>In article <3v40i0$o2b at grape.epix.net> Dave Peters <dpeters> writes:
>>I've been wondering....
>>Could the Reston form of Ebola somehow be the key to a vaccine for the 
>>deadly Ebola Zaire virus?
>It's not a completely wild idea, but it's unlikely to work.  We had a 
>disucssion about this some time ago.
> [...]  
> [...]  that there is some suggestion that Ebola (like Dengue) 
>has antibody-mediated enhancement of infection and so Reston accination 
>might actually make things worse.  Again, without a good experimental 
>system thsi is all guesswork; and the risks of a bad guess are terrible.

What about a massive dose of dead viruses?  Is there a good reason killed
viruses wouldn't cause the appropriate antibody generation, without actually
infecting somebody with an immuno-threatening disease?

(Ob warning: I'm no virologist.)
(line counter food:
| Paul R. Wilson, Comp. Sci. Dept., U of Texas @ Austin (wilson at cs.utexas.edu)
| Papers on memory allocators, garbage collection, memory hierarchies,
| persistence and  Scheme interpreters and compilers available via ftp from 
| ftp.cs.utexas.edu, in pub/garbage or http://www.cs.utexas.edu/users/oops/)      

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