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Polio vaccination

Beck, Melinda beck.fpg at MHS.UNC.EDU
Fri Oct 28 14:03:53 EST 1994


The paper you may be thinking about is J. Gen Virol (1986) 67:693-706  
Antigenic and molecular evolution of the vaccine strain of type 3 
poliovirus during the period of excretion by a primary vaccinee.  Also an 
interesting read is Holland et al. Science 215:1577-1585: Rapid evolution 
of RNA genomes.

Mark A. Williams writes:

>I vaguely remember a paper in Nature (?) several years ago in which the
>author monitored the infectivity of the virus his baby shed after 
(Sabin)
>immunization.  As I remember, he found the reversion rate was just 
slightly
>slower than the rate of neutralizing antibody production.  Does anyone 
have
>the reference?
>/////////////////////////////////////////////////////////////////////////
///////
>Mark A. Williams
Cytel Corporation
mwcytel at nic.cerf.net




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