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A-G and C-U changes

Fri Apr 15 18:40:03 EST 1994

Someone (ZXiong in Arizona I think) asked about why there should be such a high
 frequency of A-G and C-U changes in viruses. Marilyn Roossinck came up with a
very logical answer to this, namely the high stability of G-U pairing in RNA mo
lecules. From + strand to - strand the G would change to U, and in the replicat
ion from - to + strand again, the U changes to A; net change G to A. The same w
ith A to U and the U to G (A-G net), or C to G and then G to U (C-U net) or U t
o G and G to C (U-C net). Seems to make sense. Thank Marilyn.

J. de Miranda
CIBCM, U. of Costa Rica
joachim at ucrvm2.bitnet

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