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Inhibition of DSI Kinase by Influenza

mpavon at cnbvx3.cnb.uam.es mpavon at cnbvx3.cnb.uam.es
Thu Jun 24 07:20:47 EST 1993


In article <01GZODLKDFJQ9GVCCN at delphi.com>, HPUTZ at BIOTECHNET.COM writes:
> 
> 
> I'm a newcomer to this bulletin board and since I have yet to hear
> from any of you, I thought that I would try to get the ball rolling.
> 
> It is common knowledge amongst virologists that influenza, along with
> many other viruses , is capable of blocking the shut down of host
> cell protewin synthesis by inhibiting the interferon induced DSI
> kinase pathway.  I was wondering if there n is any new data and/or
> ideas as to how this mechanism works?
> 
> Henry Putz
> Dept. of Virology and Oncopharmacology
> Sterling Winthrop Pharmaceuticals


Hi, Mr. Putz.

My name is Miguel Pavon, and I am working in this area.
You should read this reference:
Katze et al. (1988). J. Virol 62, 3710-3717

and also...

Lee et al. (1992). J. Biol. Chem. 267, 14238-14243.

in wich the demonstrate tah a cellular factor of 58.000 Da is induced in
influenza infeccion and is responsible for the inhibition of p68 DAI.

Bye !!



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