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Peer Review of Captan (fungicide)

Charles Miller rellim at tulane.edu
Mon Jul 21 14:40:39 EST 2003


------ Forwarded Message
From: Patricia Nance <nance at TERA.ORG>
Reply-To: General Toxicology Discussions <TOXLIST at ESC.SYRRES.COM>
Date: Mon, 21 Jul 2003 14:08:43 -0400
To: TOXLIST at ESC.SYRRES.COM
Subject: Peer Review on Captan

FOR IMMEDIATE RELEASE
July 21, 2003 

Contacts: 

Joan E. Strawson, MS, JD, Toxicology Excellence for Risk Assessment (TERA )
910-245-3138 


Toxicology Excellence for Risk Assessment (TERA) Announces Captan Peer
Review Meeting 

Toxicology Excellence for Risk Assessment (TERA) is pleased to announce that
a scientific peer review of a cancer assessment for captan will be held on
September 3-4, 2003 at the University of Cincinnati.  A Peer Review Panel
will review a document that describes a cancer weight-of-evidence assessment
for the pesticide captan.  This document has been prepared by VJP
Consulting, Inc. and C. Wilkinson, LLC on behalf of the Captan Task Force.
More information regarding the meeting, such as logistics, agenda,
assessment document, and panel charge can be found on TERA¹s website
http://www.tera.org/peer/captan/captanwelcome.htm
<http://www.tera.org/peer/captan/captanwelcome.htm>

Background 

Captan has been in use as a nonselective fungicide for over fifty years.
EPA currently classifies captan as a ³probable human carcinogen² using their
1986 guidelines for cancer risk assessment; the weight of evidence
characterization has not been updated using EPA¹s more recent draft
guidelines.  Registrants as well as other investigators have developed
additional data that can be used to describe a mode of action for captan.
In 2001, the Captan Task Force (CTF) requested that EPA (OPP) re-evaluate
captan under its current draft cancer risk assessment guidelines.  The
Agency was not able to allocate resources to this task, reflecting budgetary
constraints and higher priorities.  The Agency, however, saw value in
addressing this issue, particularly with the pending tolerance reassessments
for other B2 compounds, and agreed in principle with the proposal to
reevaluate captan by using an independent Third Party review.  This
alternative approach is an option EPA is making available to the
Registrants; that is, while it is noted as a viable approach, the Agency is
not directing that a Third Party review be undertaken.

The document to be reviewed presents a cancer hazard assessment and weight
of evidence narrative for captan following EPA¹s 2003 Draft Final Guidelines
for Cancer Risk Assessment.  The objective of this peer review is to review
the document for the validity of the arguments and conclusions regarding the
characterization of captan.   The panel will consider all relevant data;
resolve all questions posed; or, specify where insufficient data are
available for resolution of specific questions.  Principles of sound science
will be used throughout this review process.


Patricia Nance, M.A., M.Ed.
Toxicology Excellence for Risk Assessment (TERA)
Ph. 513-542-7475 x25
nance at tera.org 
www.tera.org <file://www.tera.org>


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