------ Forwarded Message
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Thu, 27 Feb 2003 13:49:36 -0500
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group - UPDATE - February 27, 2003
DNA Repair Interest Group - UPDATE - February 27, 2003
1. VIDEOCONFERENCE - Mar 11, 2003 - Tues 12:30 PM - Dr. Sankar Mitra,
Univ of Texas, Galveston - Oxidative Damage Repair and Its Co-ordination
in the Mammalian Genome.
2. DNA REPAIR GENE WEBSITES
3. CONFERENCES - International Congress of Photochemistry; DNA Repair
and Mutagenesis: from Molecular Structure to Biological Consequences;
International Congress of Photobiology
4. POST DOC AND EMPLOYMENT OPPORTUNITIES: New York, NY; Boston, MA;
Portland, OR; Ontario, Canada; Boston, MA; Saskatchewan, Canada;
Washington, D.C.; Pittsburgh, PA
5. COMMERCIAL REAGENT SOURCES
6. Electronic Contacts
1.0 DNA REPAIR VIDEOCONFERENCE:
Mar 11, 2003 - Tues 12:30 PM - Dr. Sankar Mitra, Univ of Texas, Galveston
- Oxidative Damage Repair and Its Co-ordination in the Mammalian Genome. -
Origin: Bethesda
VIDEOCONFERENCE LOCATIONS: ; Building 45 (NATCHER) Room H, Bethesda, MD
(origin); Room 1E03 GRC Baltimore, MD Lawrence Livermore Labs, Livermore,
CA; Univ of Michigan, Ann Arbor; University of Pittsburgh; MD Anderson,
Smithville, TX; Building 101 Room B200, NIEHS, Research Triangle Park, NC;
State University of New York, Stony Brook, NY; Univ of Kentucky,
Lexington, KY; Building 549, Conference Room A, FCRDC, Frederick, MD;
Brookhaven National Labs, Upton, NY; Univ of Texas, Galveston and live on
the internet at http://videocast.nih.gov
1.1 DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
1.1.1 FUTURE VIDEOCONFERENCES:
Note: The talk by Dr. Susan Wallace scheduled for Feb 18, 2003 was
unfortunately snowed out and will be rescheduled for next season.
Apr 15, 2003 - Tues 12:30 PM - Dr. Qingyi Wei, M.D. Anderson, Houston, Tx
- DNA Repair Function, Polymorphisms and Cancer Risk in the General
Population - Origin: Smithville
May 20, 2003 - Tues 12:30 PM- Dr. Errol Friedberg, Univ of Texas
Southwestern, Dallas, Tx - History of DNA Repair - Origin: Smithville
June 17, 2003 - Tues 12:30PM - Talks by Post Doctoral Fellows - Dr. John
Bradsher, NCI, NIH, Roles of the CS proteins in Nucleotide Excision Repair
and Transcription; Tom Rosenquist, SUNY, NEIL proteins and base excision
repair in mice; Karen Vasquez, Smithville, TX - titleTBA.
1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
To date 53 of these videoconferences have been archived and are available
for viewing at your leisure on the internet. You will need a web browser
(with a high speed link) and free Real Video software. Setup details and
access are available at the NIH videocast website:
http://videocast.nih.gov. Go to Past events; DNA Repair Interest Group
Sessions.
Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!
Jan 21, 2003 - Tues 12:30PM - Dr. Jack Taylor, NIEHS - Epidemiologic
studies of DNA repair gene polymorphisms and cancer risk - Origin: NIEHS
Dec 17, 2002 - Dr. John Tainer, UC Berkeley - Conformational Controls and
DNA Repair Coordination - [Note: The posting of this talk will be delayed
at the request of the speaker.]
Nov 12, 2002 - Dr. Rob Sobol, Univ of Pittsburgh - DNA Base Damage and
Repair Intermediates: Out of the Pan and into the Fire [Note: The posting
of this talk will be delayed at the request of the speaker.]
Oct 15, 2002 - Dr. Al Fornace, NCI - Convergence of the p53 and MAP kinase
stress signaling pathways after UV radiation
Sept 17, 2002 - Dr. Dale Ramsden, UNC - DNA Double strand break repair
Note: This videoconference has just been posted!
June 18, 2002 - Dr. David Chen - Lawrence Berkeley National Lab - Role of
DNA-PK in Cellular Responses to DNA damage
May 21, 2002 - Dr. Mark J. Schofield - NIH, Bethesda - DNA mismatch
repair; Dr. Sunitha Yanamadala - Univ of Michigan - Role of Mismatch
Repair Proteins in Signaling p53 and Apoptosis; Dr. Federica Marini - Univ
of Pittsburgh - A human DNA helicase homologous to the DNA crosslink
sensitivity protein mus308
Apr 16, 2002 - Dr. Philip Hanawalt - Half a century of DNA repair: An
historical perspective
Mar 19, 2002 - Dr. Alan Tomkinson - Univ of Texas, San Antonio -
Mechanisms of DNA End Joining
Feb 19, 2002 - Dr. Yves Pommier - NCI - Nucleotide excision
repair-dependent cytotoxicity of a novel anticancer agent, ecteinascidin
743
Jan 15, 2002 - Dr. Tom Kunkel- NIEHS - Recent studies of DNA Mismatch
Repair
Dec 18, 2001 - Dr. Richard Wood - Univ of Pittsburgh- Tolerating damaged
DNA
Nov 13, 2001 - Dr. J. Christopher States - University of Louisville-
Cisplatin regulation of XPA expression in ovarian cancer cells [Note: This
conference was just posted!]
Oct 24, 2001 -UV, p53 AND SKIN CANCER- Douglas E. Brash, Ph.D., Yale
University, New Haven, CT. This 30 min videotape was presented to the
Royal College of Pathologists, London, England.
Oct 16, 2001 - Dr. Daniel Yarosh - Applied Genetics - Reduction of Skin
Cancer in XP Patients Treated Topically with DNA Repair Enzymes
June 19, 2001 - Dr. James Cleaver -Univ of California, San Francisco, CA -
History of DNA Repair - Mending Human Genes
Through the miracle of videotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998,1999, 2000 and 2001
on the web site. These include talks by Drs. Anderson, Beernik,
Bogenhagen, Bohr, Brooks, Brosh, Chu, Copeland, Drotschmann, Emmert,
Essigman, Fornace, George, Glazer, Grossman, Hanawalt, Jin, Kashlev,
Kraemer, Kunkel, Leadon, Liu, Ljungman, Matson, Matsumoto, McKay,
Setlow, Sharan, Sobol, Stefanini, Sung, Sutherland, Thompson, Wang, and
Woodgate.
2. DNA REPAIR GENE WEBSITES
2.1 HUMAN DNA REPAIR GENE VARIATIONS
The Environmental Genome project
http://www.niehs.nih.gov/envgenom/home.htm
of NIEHS has resequenced many genes from 90 donors.
As part of this project a website run by the Univ of Utah has a list of
SNP's in 96 human DNA repair genes:
http://www.genome.utah.edu/genesnps/cgi-bin/query.cgi?FunctionClass=DNA_Repa
ir
2.2 MOUSE DNA REPAIR MUTANTS
Dr. Errol Friedberg writes:
Version V of the "Database of Mouse Mutants With Defective Biological
Responses to DNA Damage" has been released online at:
http://pathcuric1.swmed.edu/Research/research.htm
The database will soon be published as hard copy in DNA REPAIR.
3. CONFERENCES - International Congress of Photochemistry; DNA Repair
and Mutagenesis: from Molecular Structure to Biological Consequences;
International Congress of Photobiology
[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
3.1 INTERNATIONAL CONFERENCE ON PHOTOCHEMISTRY, NARA, JAPAN - JULY 26-31,
2003
Dear Colleague;
On behalf of the International Committee and the Local Organizing
Committee it is my great pleasure to invite you the XXIst International
Conference on Photochemistry to be held in Nara, Japan from July 26 to 31,
2003.
The 1st Circular can be found at the www page at
http://dolphin.ap.eng.osaka-u.ac.jp/icp21.html.
If you wish to receive the second circular in December, 2002, please
complete the REPLY FORM at the end of this mail and return it at your
earliest convenience by e-mail (or FAX). The REPLY FORM is also available
in the 1st Circular.
If you have any questions, please feel free to e-mail to the Secretary
General of the
Conference.
Sincerely Yours,
Professor H. Masuhara, Chairperson
XXIst International Conference on Photochemistry
Department of Applied Physics
Osaka University, Suita,
Osaka 565-0871, Japan
Professor K. Obi, Chairperson
XXIst International Conference on Photochemistry
Department of ChemistryJapan Woman's University, Bunkyou-ku,
Tokyo 112-8681, Japan
All correspondence concerning the Conference should be addressed to:
Professor N. Nakashima, Secretary General
XXIst International Conference on Photochemistry
Department of Chemistry, Osaka City University,
Sugimoto, Sumiyoshi, Osaka 558-8585, Japan
E-mail : icp21 at sci.osaka-cu.ac.jp
phone &Fax: +81-6-6605-2552
3.2 DNA REPAIR AND MUTAGENESIS: FROM MOLECULAR STRUCTURE TO BIOLOGICAL
CONSEQUENCES - BERMUDA, DECEMBER 7-13, 2003.
Dear Colleagues,
We are writing to let you know that we will be organizing an ASM
Conference entitled "DNA Repair and Mutagenesis: From Molecular Structure
to Biological Consequences" sponsored by the American Society for
Microbiology to be held at the Fairmont Southampton Princess, Bermuda,
December 7-13, 2003. The conference will bring together the various
subdisciplines that collectively comprise the field of DNA Repair and
Mutagenesis. Meetings of this type have been held at approximately four
year intervals since 1974, the preceding one in this informal series
having been at Hilton Head, South Carolina in 1999, and have played a
critical role in the development of this exciting area of research.
Speakers will include: Genevive Almouzni, Lorena Beese, Serge Boiteux,
Jaap Brouwer, Keith Caldecott, Judith Campisi, Gilbert Chu, Priscilla
Cooper, Titia de Lange, John Diffley, Sylvie Doubli, Jean-Marc Egly,
Stephen Elledge, Tom Ellenberger, Rick Fishel, Marco Foiani, Errol
Friedberg, Robert Fuchs, James Haber, Fumio Hanaoka, Phil Hanawalt, Jan
Hoeijmakers, Peggy Hsieh, Ian Hickson, Stephen Jackson, Maria Jasin, Penny
Jeggo, Joe Jiricny, Roland Kanaar, Richard Kolodner, Stephen
Kowalczykowski, Thomas Kunkel, Tony Leadon, Alan Lehmann, Tomas Lindahl,
Bndicte Michel, Sankar Mitra, Paul Modrich, Leon Mullenders, Tanya Paull,
John Petrini, Louise Prakash, Miroslav Radman, Rodney Rothstein, Leona
Samson, Alain Sarasin, Erling Seeberg, Jesper Svejstrup, John Tainer,
Shunichi Takeda, Kiyoji Tanaka, Graham Walker, Susan Wallace, Stephen
West, Sam Wilson, Richard Wood, Roger Woodgate, and Wei Yang.
Some additional speakers on timely topics will be invited closer to the
date of the meeting, and furthermore, speakers will be chosen from among
the submitted abstracts for shorter presentations.
Careful thought has been given to the choice of the site and the design of
the program so that participants will be able to enjoy the type of
opportunities for informal discussions and interactions that are normally
found only at smaller meetings. A special feature of the meeting will be
travel grants to help support the participation of graduate students and
postdoctoral fellows. Additional information concerning the meeting and
the program is available at: http://www.asmusa.org/mtgsrc/dnarepair2.htm
We hope you will mark these dates on your calendars. We look forward to
seeing you in Bermuda in December 2003!
Best Wishes
Graham Walker, Susan Wallace, and Priscilla Cooper
3.3 INTERNATIONAL CONGRESS ON PHOTOBIOLOGY - JEJU ISLAND, KOREA - JUNE
10-15, 2004.
The 14th International Congress on Photobiology sponsored by the
International Union of Photobiology and hosted by the Korean Society of
Photoscience, Photobiology Association of Japan, and Asia and Oceania
Society for Photobiology will be held June 10-15, 2004, on the island of
Jeju, Korea. Both Korean Society of Photoscience, Korean Photodynamic
Association, and Asia and Oceania Society for Photobiology will also hold
their annual meetings in conjunction with the Congress at the same time.
More details can be found at:
http://photos.or.kr/ICP2004 (ICP is case-sensitive)
I would like to invite you to register to participate in the Congress by
visiting the website and filling out the registration form therein. To
make the Congress successful, your suggestions and contributions are
essential and will be greatly appreciated by the Organizing Committee. In
order to make the Congress scientifically attractive, we plan to organize
nearly 50 symposia and 10 special lectures. In addition, we are planning
to present a national photobiology-society sponsored Plenary Lecture each
day of the
Congress.
The Congress venue is the Island of Jeju. It is one of the most beautiful
islands in the world. It offers many sightseeing and leisure attractions.
Bring your family and friends. You will enjoy it.
See you all here in Jeju, Korea, in Year 2004!
Best wishes,
Pill-Soon Song
Congress President-ICP2004
4. POST DOC AND EMPLOYMENT OPPORTUNITIES: Galveston, TX; New York,
NY; Boston, MA; Upton, NY; Portland, OR; Ontario, Canada; Boston, MA;
Saskatchewan, Canada; Washington, D.C.; Pittsburgh, PA [Note: Check the
list for more Job Opportunities on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
4.1 POSTDOCTORAL POSITIONS IN DNA REPAIR - GALVESTON, TX
Postdoctoral positions are available in the laboratories of Satya and
Louise Prakash studying DNA repair processes, mechanisms promoting
transcription and replication through DNA lesions, translesion synthesis
DNA polymerases and the role of ubiquitin-conjugation in polymerase switch
at the lesion site, in yeast and humans.
Interested individuals should send a curriculum vitae, a summary of Ph.D.
research, and names and contact information of two references to:
-Dr. Louise Prakash, Sealy Center for Molecular Science, The University
of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1061,
USA. -Telephone: (409) 747-8601; Fax: (409) 747-8608; E-mail:
l.prakash at utmb.edu
UTMB hires only individuals authorized to work in the United States. An
Affirmative Action/Equal Opportunity employer, M/F/D/V.
4.2 POST DOCTORAL POSITION - COLUMBIA UNIVERSITY, NEW YORK
A postdoctoral position is available immediately at the Department of
Radiation Oncology, Center for Radiological Research, Columbia University
to pursue studies of signal transduction pathway(s) involved in radiation
induced DNA damage and bystander response in mammalian cells. Candidate
with a recent a Ph.D. degree in Biochemistry, Molecular biology or Cell
biology is required. Experience in cell culture, protein biochemistry and
signal transduction research experience is preferred.
Interested candidates can submit their resume, areas of research interests
and three letters of recommendations to either
Prof. Charles R. Geard or Dr. A.S. Balajee
Department of Radiation Oncology
Center for Radiological Research
College of Physicians and Surgeons
Columbia University, VC-11, Room 243
168th Street, 630 West
New York, NY 10032.
Informal enquiries can be made to Dr. A.S. Balajee (ab836 at columbia.edu).
4.3 POSTDOCTORAL POSITION - ALKYLATION DAMAGE - BOSTON, MA
Postdoctoral position - Biological Engineering Division Massachusetts
Institute of Technology, Boston, MA. A postdoctoral position is available
in the lab of Leona D. Samson to study the biological effects of
alkylation damage. Research areas include: (1) exploring the molecular
basis of cellular signaling in response to DNA alkylation damage; (2)
alkylation damage-induced global transcriptional responses; (3) functional
genomic approaches (genomic phenotyping) to identifying novel recovery
pathways; (4) transgenic and knockout mice to study the influence of
alkylation damage on apoptosis, mutation, genome stability and
tumorigenesis; (5) gene therapy approaches to suppressing bone marrow
toxicity. Experience in biochemistry, molecular biology, cell biology,
DNA repair, or knockout/transgenic mouse technology is desired.
Selected Publications:
Hickman, M. and Samson, L.D. (1999) Role of DNA mismatch repair and p53 in
signaling induction of apoptosis by alkylating agents. Proc. Natl. Acad.
Sci., 96: 10764-10769.
Roth, R.B., and Samson, L.D. (2000) Gene transfer to suppress bone marrow
alkylation toxicity. Mutation Research, 462:107-120.
Lau, A.Y., Wyatt, M.D., Glassner, G., Samson, L.D., and Ellenberger, T.E.
(2000) Molecular basis for discriminating between normal and damaged bases
by the human alkyladenine glycosylase, AAG. Proc. Natl. Acad. Sci,
97(25):13573-13578.
Jelinsky, S., Estep, P., Church, G., and Samson, L. D. (2000) Regulatory
networks revealed by transcriptional profiling of damaged Saccharomyces
cerevisiae cells: Rpn4 links base excision repair with proteasomes,
Molecular and Cellular Biology, 20 (21):8157-8167.
Roth, R. and Samson, L.D. (2002) 3-methyladenine DNA
glycosylase-deficient Aag null mice display unexpected bone marrow
alkylation resistance, Cancer Research 62, 656-660.
Begley, T.J., Rosenbach, A.S., Ideker, T. and Samson, L.D. (2002) Recovery
Pathways in S. cerevisiae Revealed by Genomic Phenotyping and Interactome
Mapping, Molecular Cancer Research, in press
Begley T.J. and Samson, L.D. (2003) AlkB mystery solved: Oxidative
demethylation of N1-methyladenine and N3-methylcytosine adducts by a
direct reversal mechanism, Trends in the Biochemical Sciences, in press
Please send CV and 3 letters of Reference to:
Leona D. Samson
Ellison American Cancer Society Research Professor
Biological Engineering Division, and
Director of the Center for Environmental Health Sciences
Massachusetts Institute of Technology
77 Massachusetts Avenue, 56-235
Cambridge, MA 02139
or via email: lsamson at mit.edu
4.4 POSTDOCTORAL POSITION-NERVOUS SYSTEM DNA REPAIR, PORTLAND, OR
A postdoctoral position is available immediately to study the role of DNA
damage and DNA repair in the nervous system. Particular emphasis is on
understanding the role of BER and NER in maintaining the integrity of
neurons and other cell types of the central nervous system. Currently
funded projects involve the use of whole animal and cell culture models
from transgenic/knockout DNA repair mutant mice to explore the
relationship between neuronal cell death and DNA damage during development
and in age-related neurodegenerative disease (e.g., Parkinson's,
Alzheimer's, and Lou Gehrig's disease). PhD candidates (less than 5 yrs
experience) with a strong background in molecular or cell biology and DNA
repair and experience in mammalian cell culture, protein biochemistry,
gene expression, protein-protein interaction, DNA microarrays are
encouraged to apply.
For more information, send an email to the address below. To apply, please
send your C.V., a description of your research experience, and the names,
addresses, telephone numbers and email addresses of three references to:
Glen Kisby, PhD
Associate Professor
Ctr for Res on Occup
& Environ Toxicol (CROET)
Oregon Health & Science University (OHSU)
3181 SW Sam Jackson Park Rd
Portland, OR 97201-3098
E-mail: kisby at ohsu.edu
Portland is an affordable centrally located city in the beautiful state of
Oregon. The University is only 1 h away from year round skiing at Mt Hood,
the Pacific Ocean, and the scenic deserts of eastern Oregon. The campus
contains a large group of distinguished faculty with special emphasis on
the nervous system. CROET is a unique research institute with faculty that
conduct applied research in the workplace (i.e., epidemiology) and basic
research at the cellular and molecular level.
4.5 POSTDOCTORAL POSITION IN MAMMALIAN DNA REPAIR DEPARTMENT OF BIOLOGY,
McMASTER UNIVERSITY, ONTARIO, CANADA
A postdoctoral position is available immediately to study the DNA repair
pathways in mammalian cells. Our laboratory is particularly interested in
the mechanisms of inducible DNA repair pathways following exposure to UVA,
UVB and UVC and how deficiencies in DNA repair play a role in human
disease. Research areas include the role of several human ERCC genes in
inducible DNA repair as well as several aspects of the DNA repair
deficiency in cells from patients with xeroderma pigmentosum, Cockayne
syndrome, Li-Fraumeni syndrome and ataxia telangiectasia. Our laboratory
has developed a number of techniques to study DNA repair using
adenoviruses as probes and expression vectors and the application of these
techniques to other areas of mammalian DNA repair are also possible
research areas in my laboratory.
The position is initially for one year (minimum starting salary of
$30,000) with the possibility of extension for two further years.
Candidates with a recent Ph.D., a background in cell biology, molecular
biology and genetics, some experience in mammalian cell culture and a good
knowledge of both written and spoken English are encouraged to apply.
Please send a CV and the names and addresses (including email address and
telephone number) of three references to:
Andrew J. Rainbow, Ph.D.
Department of Biology
McMaster University
Hamilton, Ontario L8S 4K1
Canada.
Telephone: (905)-525-9140, ext. 23544
Fax: (905)-522-6066
Email: rainbow at mcmaster.ca
Website:
http://www.science.mcmaster.ca/biology/faculty/rainbow/rainbow.htm
4.6 POSTDOCTORAL/RESEARCH ASSOCIATE POSITIONS - BOSTON
Two openings available immediately to study the role of AP endonuclease in
the cell physiology and biochemistry of DNA base excision repair. We are
a dynamic group in a young department with lots of opportunity. The
successful candidate will be smart, enterprising and hard working. We
need you!
Contact: Phyllis Strauss, Northeastern University, Boston MA 02115,
e-mail: p.strauss at neu.edu.
4.7 POSTDOCTORAL POSITIONS - UNIVERSITY OF SASKATCHEWAN, CANADA
Two postdoctoral positions are available immediately. One is to study DNA
postreplication repair and mutagenesis in mammalian cells and in a
transgenic mouse model. The second position is to study molecular
mechanisms of gene regulation in response to DNA damage, using budding
yeast as a model eukaryote.
Candidates with recent Ph.D. and background in biochemistry, cell biology,
molecular biology and genetics are encouraged to apply. Annual salary
begins with $32,000 - $35,000, based on experience. Please send CV and
names of three references with contact information to:
Wei Xiao, Ph.D.,
Professor, Department of Microbiology and Immunology
University of Saskatchewan
107 Wiggins Road
Saskatoon, SK, S7N 5E5 Canada
Tel: 306-966-4308
Fax: 306-966-4311
E-mail: wei.xiao at usask.ca
Web site:http://www.usask.ca/medicine/microbio/xiaow/
4.8 POSTDOCTORAL RESEARCH ASSOCIATE - WASHINGTON, D.C.
An NIH funded post-doctoral position is available to investigate
the genetics of melanoma using a new mouse model of UV-induced melanoma
(Nature, 413:271-2, 2001) in particular to investigate the effect of
genetic deficiencies in nucleoside excision repair on melanoma induction.
Our laboratory has had a long term interest in the effects of UV radiation
in skin cancer. We have developed an exciting new model for melanoma which
most closely recapitulates human disease and represents a strong vehicle
for melanoma investigations. The George Washington University Medical
Center is currently expanding its interest in cancer research and through
the George Washington Institute of Biomedical Sciences is affiliated with
Children's National Medical Center, Red Cross Holland Laboratories and The
Institute for Genome Research. Knowledge of DNA repair a strong
advantage. Excellent command of English is essential.
Please send applications to:
Dr F. Noonan, Professor, Department of Environmental and Occupational
Health, George Washington University Medical Center, Ross Hall, Rm 113,
2300 Eye St., NW, Washington DC, 20037.
Tel: 202 994 3970
email: drmfpn at gwumc.edu or fpn at gwu.edu
The George Washington University Medical Center is an equal opportunity
employer. GWUMC is conveniently located in downtown DC next to the Foggy
Bottom Metro.
4.9 POST-DOCTORAL FELLOWSHIP - DNA REPAIR AND DAMAGE AVOIDANCE -
PITTSBURGH, PA
Mammalian Base Excision Repair
The University of Pittsburgh Cancer Institute
Hillman Cancer Center
A postdoctoral / Research Associate position is available in my lab to
study mammalian DNA repair and damage avoidance. Research areas include:
1) function of X and Y-family polymerases; 2) signal transduction/cell
cycle checkpoints elicited by DNA damage and repair intermediates; 3) DNA
base damage-induced transcriptional profiles using DNA microarrays and
SAGE; 4) transgenic and knockout/knockin mice to study the role of
polymerases in base excision repair, lesion avoidance, genome stability
and tumorigenesis. [see Sobol et al., ProcNatl Acad Sci U S A 99, 6860-5.
(2002); Sobol et al., Nature 405, 807-10. (2000); Sobol et al., Nature
379, 183-6. (1996)]. Experience in biochemistry, molecular biology, cell
biology, DNA repair, or knockout/transgenic mouse technology is desired.
CV and 3 letters of Reference can be sent to:
Robert W. Sobol, Ph.D.,
Hillman Cancer Center,
5117 Centre Avenue, Room 2.3,
Pittsburgh, PA 15232
or via email: rws9 at pitt.edu.
The Hillman Cancer Center opened in July 2002 in a newly-built,
free-standing 350,000 sq. ft. facility integrating basic, translational
and clinical cancer research with patient care. The Center serves as a
critical resource in the region as UPCI is the only NCI-designated
Comprehensive Cancer Center within a 100-mile radius and one of only six
within 200 miles of Pittsburgh. The Center features a Laboratory Pavilion
devoted to basic research programs in biological therapeutics, immunology,
molecular virology, molecular oncology, and molecular therapeutics and
drug discovery. The Center also features an Ambulatory Pavilion devoted to
treatment, prevention and early detection, screening, genetic counseling,
nutritional counseling, behavioral medicine, grief counseling, and
community outreach. The two pavilions are connected by a three-story
atrium lobby that offers a warm welcome to patients, visitors, physicians,
scientists and staff and that will create synergy between UPCI's rapidly
growing basic research and clinical activities. The Center integrates
full-time faculty with more than 50 office-based oncology practices that
currently exist as part of UPCI's extensive clinical network that treat
more than 25,000 patients annually. State-of-the art facilities include
small animal care facility, BSL-3 laboratory, flow cytometry suite and
vector production facilities. Faculty having laboratories in the Hillman
Cancer Center are full members of University of Pittsburgh departments
with ready access to University of Pittsburgh core facilities, graduate
programs and seminar series. The unique collegial and collaborative
research environment at the Hillman Cancer Center promises to promote the
search for fundamental causes and cures for cancers.
http://www.upci.upmc.edu/internet/research/index.html
Located at the confluence of three rivers, Pittsburgh is one of America's
most beautiful and livable cities. Active arts and cultural communities,
renown sports teams and interactions between two major universities,
University of Pittsburgh and Carnegie-Mellon University, make Pittsburgh
an attractive spot for leading researchers, students and post-doctoral
fellows.
The University of Pittsburgh is an Affirmative Action Equal Opportunity
Employer
5. COMMERCIAL REAGENT SOURCES
[Note: There are more commercial reagent sources listed on the DNA Repair
interest group website: http://www.nih.gov:80/sigs/dna-rep/ These
sources are listed as a convenience to our readers and do not constitute
an endorsement of any of these companies or their products.]
5.1 Novus Biologicals, Inc., Littleton, CO - Antibodies for DNA Repair
Research
(http://www.novus-biologicals.com/research.php/8) and other research
applications (www.novusbio.com). New antibodies include FANCD2, XRCC(2&3),
RAD51(B,C,&D), Tankyrase, DMC-1, DNA polymerase iota, and PAK6.
5.2 Santa Cruz Biotechnology, Inc, Santa Cruz, CA - Antibodies for
research applications. Please find specific product information at
http://www.scbt.com
5.3 Austral Biologicals, Inc, San Ramon, CA. - Antibodies for research
applications.
Please visit our web site: http://www.australbio.com
5.4 Enzymax, Lexington, KY - Good news to the DNA repair community! Many
DNA repair enzymes and proteins are now available from Enzymax
(www.enzymax.net). Purified proteins include Y family DNA polymerases,
various DNA glycosylases, AP endonucleases, PCNA, Ku70, Ku80, p53, etc.
Molecular reagents, PCR reagents, and custom DNA construction and protein
purification are also available.
Enzymax, maximizing your research productivity!
Xiaohua (Michelle) Wu
Enzymax LLC
TEL: (859) 257-2300 ext. 280
www.enzymax.net
6 ELECTRONIC CONTACTS:
6.1 Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.
6.2 Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject blank. In the message field, type in: subscribe
DNARepair-L your name
Alternatively, by filling out the form on the website
(http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the
e-mail list and have your name posted on the website. If you want your
name to be listed you can fill out the "Join the SIG" form on the web site
and add your name to the listing of members. If you are not at NIH then
be sure to click the "other" box and then fill in the name of your
institution.
6.3 Archives of these listserve mailings can be found at
http://list.nih.gov/archives/dnarepair-l.html or via links from
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
6.4 I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 950 scientists around the world who are
interested in DNA repair.)
Kenneth H. Kraemer, M.D.
Chief, DNA Repair Section
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda, MD 20892
301-496-9033 FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
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