post-docs in DNA damage and repair

Miller 4amiller at bellsouth.net
Wed Sep 4 19:11:14 EST 2002


        The Carcinogen-DNA Interactions Section, National Cancer
Institute, NIH -  Bethesda, MD - has a Post-doctoral position available to
study mechanisms of interaction between chemical carcinogens and DNA.
Investigations include both the extent of DNA adduct formation and
persistence, and the biological consequences of DNA damage occurring in
nuclear DNA and in specific structural (mitochondrial, telomeric) genomic
regions.  The DNA adduct data are correlated with specific effects of
carcinogen/drug exposure, including tumorigenesis, clinical response,
specific toxicities, functional impairment of target organs and organelles
and changes in gene expression.  The primary focus is on events that occur
in both animal models and human subjects, with the intention of applying
the knowledge gained to either reduce human toxicity or enhance human
clinical response.  The current opening is for a Postdoctoral Fellow to
study the effects of polycyclic aromatic hydrocarbons (PAHs).  Molecular
dosimetry studies of individuals in China exposed to high levels of
dietary PAHs and experiencing high esophageal cancer mortality are in
progress.  Highly-sophisticated quantitative immunoassays and
immunohistochemistry are being employed to explore the relationship
between PAH-DNA adduct formation in human esophagus and esophageal cancer
risk, and to examine preneoplastic events in the human esophagus.  Also,
human PAH exposures and tumorigenesis are being modeled in double
transgenic mice deficient in DNA repair and tumor suppressor capacity.

Secure funding for these projects is provided by the NCI Intramural
research program.  The position duration may be up to 5 years for U.S
citizens and green card holders and up to 3 years for non-citizens.
Applicants are expected to have effective oral and written skills in
English, and should not have received the MD or PhD degree more than 5
years prior to submitting the application.

Interested parties should send a current Curriculum Vitae and 3 letters of
recommendation to
Miriam C. Poirier Ph.D.,
Head, CDI Section, National Cancer Institute, NIH,
37 Convent Dr -MSC4255, USA 20892-4255.
TEL: 301-402-1835; FAX 301-402-8230; EMAIL poirierm at exchange.nih.gov


        An NIH funded post-doctoral position is available to investigate
the genetics of melanoma using a new mouse model of UV-induced melanoma
(Nature, 413:271-2, 2001) in particular to investigate the effect of
genetic deficiencies in nucleoside excision repair on melanoma induction.
Our laboratory has had a long term interest in the effects of UV radiation
in skin cancer. We have developed an exciting new model for melanoma which
most closely recapitulates human disease and represents a strong vehicle
for melanoma investigations. The George Washington University Medical
Center is currently expanding its interest in cancer research and through
the George Washington Institute of Biomedical Sciences is affiliated with
Children's National Medical Center, Red Cross Holland Laboratories and The
Institute for Genome Research.  Knowledge of DNA repair a strong
advantage. Excellent command of English is essential.

Please send applications to:
Dr F. Noonan, Professor, Department of Environmental and Occupational
Health, George Washington University Medical Center, Ross Hall, Rm 113,
2300 Eye St., NW, Washington DC, 20037.
Tel: 202 994 3970
email: drmfpn at gwumc.edu or fpn at gwu.edu
The George Washington University Medical Center is an equal opportunity
employer. GWUMC is conveniently located in downtown DC next to the Foggy
Bottom Metro.


Mammalian Base Excision Repair
The University of Pittsburgh Cancer Institute
Hillman Cancer Center

A postdoctoral / Research Associate position is available in my lab to
study mammalian DNA repair and damage avoidance. Research areas include:
1)  function of X and Y-family polymerases; 2) signal transduction/cell
cycle checkpoints elicited by DNA damage and repair intermediates; 3) DNA
base damage-induced transcriptional profiles using DNA microarrays and
SAGE; 4) transgenic and knockout/knockin mice to study the role of
polymerases in base excision repair, lesion avoidance, genome stability
and tumorigenesis. [see Sobol et al., Proc Natl Acad Sci U S A 99, 6860-5.
(2002); Sobol et al., Nature 405, 807-10. (2000); Sobol et al., Nature
379, 183-6. (1996)]. Experience in biochemistry, molecular biology, cell
biology, DNA repair, or knockout/transgenic mouse technology is desired.

CV and 3 letters of Reference can be sent to:
Robert W. Sobol, Ph.D.,
Hillman Cancer Center, 5117 Centre Avenue, Room 2.3,
Pittsburgh, PA 15232
or via email: rws9 at pitt.edu.

The Hillman Cancer Center opened in July 2002 in a newly-built,
free-standing 350,000 sq. ft. facility integrating basic, translational
and clinical cancer research with patient care. The Center serves as a
critical resource in the region as UPCI is the only NCI-designated
Comprehensive Cancer Center within a 100-mile radius and one of only six
within 200 miles of Pittsburgh. The Center features a Laboratory Pavilion
devoted to basic research programs in biological therapeutics, immunology,
molecular virology, molecular oncology, and molecular therapeutics and
drug discovery. The Center also features an Ambulatory Pavilion devoted to
treatment, prevention and early detection, screening, genetic counseling,
nutritional counseling, behavioral medicine, grief counseling, and
community outreach. The two pavilions are connected by a three-story
atrium lobby that offers a warm welcome to patients, visitors, physicians,
scientists and staff and that will create synergy between UPCI's rapidly
growing basic research and clinical activities. The Center integrates
full-time faculty with more than 50 office-based oncology practices that
currently exist as part of UPCI's extensive clinical network that treat
more than 25,000 patients annually. State-of-the art facilities include
small animal care facility, BSL-3 laboratory, flow cytometry suite and
vector production facilities. Faculty having laboratories in the Hillman
Cancer Center are full members of University of Pittsburgh departments
with ready access to University of Pittsburgh core facilities, graduate
programs and seminar series. The unique collegial and collaborative
research environment at the Hillman Cancer Center promises to promote the
search for fundamental causes and cures for cancers.

Located at the confluence of three rivers, Pittsburgh is one of America's
most beautiful and livable cities. Active arts and cultural communities,
renown sports teams and interactions between two major universities,
University of Pittsburgh and Carnegie-Mellon University, make Pittsburgh
an attractive spot for leading researchers, students and post-doctoral

The University of Pittsburgh is an Affirmative Action Equal Opportunity

We are studying molecular, cellular and clinical abnormalities in patients
with defective DNA repair and possible links of these genes to disease in
the general population. Current emphasis is on xeroderma pigmentosum,
Cockayne syndrome and trichothiodystrophy.  A postdoctoral position is
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than
5 years of postdoctoral experience who has knowledge of molecular biology
and DNA repair.

To apply, send CV and bibliography and names (with contact information) of
3 references to:
Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda,  MD 20892
TEL: 301-496-9033    FAX: 301-496-8419
e-mail: kraemerk at nih.gov

NIH is an equal opportunity employer


A post-doctoral position for a U.S. citizen is immediately available in
the Dermatology Research Unit to study DNA repair in cutaneous systems.
Available projects focus on understanding regulation of nucleotide
excision repair in differentiating keratinocytes and dissecting responses
to targeted DNA damage in three-dimensional tissue models. Our laboratory
utilizes standard techniques in cell and molecular biology as well as
novel biophysical methods that we have developed. Work will be conducted
principally at the San Francisco VA Medical Center campus overlooking the
Golden Gate Bridge.

Please send inquiries with CV and names of references to:
Dennis H. Oh, M.D., Ph.D.
Assistant Professor, University of California at San Francisco
Assistant Chief, Dermatology
Dermatology Service (190)
San Francisco VA Medical Center
4150 Clement Street
San Francisco, CA 94121
E-mail: doh at orca.ucsf.edu
Phone: (415) 750-2091
FAX: (415) 751-3927


Postdoctoral position available to study the molecular mechanism of
immunoglobulin gene somatic hypermutation. This is a wonderful project for
a postdoctoral fellow who is highly motivated, independent, and creative.
Our laboratory uses the tools of biochemistry, genetics, and cell biology
to study fundamental problems in mammalian DNA repair and recombination.
We are located at the University of Washington, in Seattle, where there is
extensive opportunity for interaction and collaboration with other groups
interested in mutagenesis, recombination, repair, and genomic stability.
The institutional culture encourages and fosters research at the interface
of basic biology and medicine. Seattle is a lively city in an unusually
beautiful setting.

To apply, please send a c.v., a brief statement of research interests
and experience, and names and email addresses of three references to:

Nancy Maizels
Professor, Departments of Immunology and Biochemistry
University of Washington Medical School
Seattle, Washington 98195-7650
phone: 206-221-6876; fax: 206-221-6781
maizels at u.washington.edu

Hill, NC
Post doctoral fellowship to study the biochemical mechanisms of DNA Damage
Checkpoint Response in human cells and to develop cancer chemotherapeutic
strategies targeting DNA damage checkpoint signaling pathways. Recent
graduates with training in biochemistry, molecular biology, or cellular
biology are encouraged to apply.
Dr. Aziz Sancar
Department of Biochemistry and Biophysics
Lineberger Comprehensive Cancer Center, CB 7260
University of North Carolina School of Medicine
Chapel Hill, NC 27599-7260
E-mail: Aziz_Sancar at med.unc.edu


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