----------
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Mon, 4 Mar 2002 14:09:57 -0500
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group -UPDATE - March 4, 2002
DNA Repair Interest Group -UPDATE - March 4, 2002
1. VIDEOCONFERENCE - Mar 19, 2002 - Dr. Alan Tomkinson - Univ of
Texas, San Antonio - Mechanisms of DNA End Joining
2. NIH Seminar - March 11- Revealing the Roles of CSB, XPB and XPD in
Cockayne Syndrome
3. SKIN CANCER/p53 LECTURE ON VIDEO
4. CONFERENCES -Environmental Mutagen Society; Midwest DNA Repair
Symposium; IPAC Symposium on Photochemistry; M.D. Anderson Symposium on
Fundamental Cancer Research
5. POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Pittsburgh,
PA; Baltimore, MD; Research Triangle Park, NC; Saskatchewan, Canada;
Bethesda, MD; New Haven, CT; Ann Arbor, MI; Winston-Salem, NC
6. Electronic Contacts
1.0 DNA REPAIR VIDEOCONFERENCE:
Mar 19, 2002 - Tues 12:30PM - Dr. Alan Tomkinson - Univ of Texas, San
Antonio- Mechanisms of DNA End Joining
VIDEOCONFERENCE LOCATIONS: MD Anderson, Smithville, TX (origin); Building
45 (NATCHER) Room H, Bethesda, MD; Building 101 Room B200, NIEHS, Research
Triangle Park, NC; State University of New York, Stony Brook, NY; Room
1E03 GRC Baltimore, MD; Univ of Kentucky, Lexington, KY; Building 549,
Conference Room A, FCRDC, Frederick, MD; Lawrence Livermore Labs,
Livermore, CA; Univ of Michigan, Ann Arbor; Brookhaven National Labs,
Upton, NY and University of Pittsburgh and live on the internet at
http://videocast.nih.gov
1.1 DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
1.1.1 FUTURE VIDEOCONFERENCES:
Apr 16, 2002 - Tues 12:30PM - Dr. Philip Hanawalt - History of DNA Repair
May 21, 2002 - Tues 12:30PM - Dr. Mark J. Schofield - NIH, Bethesda - DNA
mismatch repair; Dr. Sunitha Yanamadala - Univ of Michigan - Mismatch
repair proteins in signaling p53 and apoptosis; Dr. Federica Marini - Univ
of Pittsburgh - A human DNA helicase homologous to the DNA crosslink
sensitivity protein mus308
June 18, 2002 - Tues 12:30PM - Dr. David Chen - Lawrence Berkeley National
Lab - Role of DNA-PK in Cellular Responses to DNA damage
1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
Now 42 of these videoconferences have been archived and are available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software. Setup details and access
are available at the NIH videocast website: http://videocast.nih.gov. Go
to Past events; DNA Repair Interest Group Sessions.
Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!
Feb 19, 2002 - Dr. Yves Pommier - NCI - Nucleotide excision
repair-dependent cytotoxicity of a novel anticancer agent, ecteinascidin
743
Jan 15, 2002 - Dr. Tom Kunkel- NIEHS - Recent studies of DNA Mismatch
Repair
Dec 18, 2001 - Dr. Richard Wood - Univ of Pittsburgh- Tolerating damaged
DNA
Nov 13, 2001 - Dr. J. Christopher States - University of Louisville-
Cisplatin regulation of XPA expression in ovarian cancer cells [Note:
Posting of this videoconference will be delayed at the request of the
speaker]
Oct 24, 2001 -UV, p53 AND SKIN CANCER- Douglas E. Brash, Ph.D., Yale
University, New Haven, CT. This 30 min videotape was presented to the
Royal College of Pathologists, London, England.
Oct 16, 2001 - Dr. Daniel Yarosh - Applied Genetics - Reduction of Skin
Cancer in XP Patients Treated Topically with DNA Repair Enzymes
JUNE 19, 2001 - Dr. James Cleaver -Univ of California, San Francisco, CA -
History of DNA Repair - Mending Human Genes
MAY 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics NIEHS -
Family A DNA polymerases in eukaryotic DNA replication and repair
MAR 20, 2001 - Short talks at 3 sites:
Peter Beernink, LLNL - A Second Divalent Metal Ion in the Active Site of a
New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and
its Implications for the Catalytic Mechanism
Yong Hwan Jin, NIEHS - The 3'-5' Exonuclease of DNA Polymerase d is
Redundant with
5'-flap Endonuclease Rad27/Fen1 for Processing of Okazaki Fragments
Robert M. Brosh, NIA - Molecular Interactions of the Werner Syndrome
Protein
FEB 20, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD - DNA repair
defects in premature aging disorders
JAN 16, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI -Stopped
in its tracks - RNA polymerase II as a sensor for DNA damage
Through the miracle of videotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998,1999 and 2000 on the
web site. These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate, George, Liu,
Grossman, Essigman, Emmert, Sobol, Glazer, Setlow, Kraemer, Matsumoto,
Wang, and Sung.
2. NIH Seminar - March 11, 1:00 PM - Revealing the Roles of CSB, XPB and
XPD in Cockayne Syndrome. Speaker: Dr. John Bradsher -Institut de
Genetique et de Biologie Moleculaire et Cellulaire (IGBMC) Location:
Building 10 (Clinical Center), Clin. Path. Conf. Room 2C310. For more
information contact: Dr. David Levens (301)496-2176 e-mail:
levens at helix.nih.gov (Note: This seminar will not be on video)
3. SKIN CANCER/p53 LECTURE ON VIDEO
By special arrangement we have obtained a videotape of the lecture
UV, p53 AND SKIN CANCER by Douglas E. Brash, Ph.D., Yale University, New
Haven, CT. This 30 min videotape was presented to the Royal College of
Pathologists, London, England on October 24, 2001. The videotape may be
viewed at: http://videocast.nih.gov/PastEvents.asp?c=5
4. CONFERENCES - Environmental Mutagen Society; Midwest DNA Repair
Symposium; IPAC Symposium on Photochemistry; M.D. Anderson Symposium on
Fundamental Cancer Research
[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
4.1 ANNUAL MEETING OF THE ENVIRONMENTAL MUTAGEN SOCIETY -
Anchorage, Alaska, 27 April - 2 May, 2002
"FRONTIERS BEYOND THE HUMAN GENOME"
Program Chair: Larry Loeb
The program for the 33rd Annual Meeting of the Environmental Mutagen
Society (EMS) is now available at http://www.ems-us.org/program02.html.
A number of symposia and sessions are devoted to DNA repair. These include
"Double-Stranded Breaks: The Ultimate End Game"
"Complex DNA Lesions: Repair and Mutagenesis"
"When Polymerases Are Arrested, Who Is at Fault, and What Are the
Options?"
Please check out the details of the conference at www.ems-us.org. Click on
"meetings."
Hope to see you there!
David M. DeMarini
President, EMS
demarini.david at epa.gov
4.2 Midwest DNA Repair Symposium - Cincinnati- May 4 - 5, 2002.
The 4th Annual Midwest DNA Repair Symposium will be in Cincinnati on May 4
- 5, 2002.
Please see the website for details: http://www.sbrp.uc.edu
4.3 IUPAC Symposium on Photochemistry - Budapest, Hungary, July 14-19,
2002
The home page of the XIXth IUPAC Symposium on Photochemistry is being
updated. You will find all necessary forms and deadlines, including the
form for the submission of abstracts. If you intend to present an oral
contribution, please note the deadline of March 1, 2002. Oral
presentations will be selectedby the International Scientific Committee
(ISC). The home page will be updated from time to time, as needed, so
please check it occasionally.
http://www.photoiupac.hu
Heinz Roth and Jozsef Nyitrai
4.4 55th MD ANDERSON SYMPOSIUM ON FUNDAMENTAL CANCER RESEARCH - HOUSTON,
TX, OCT 15-18, 2002
The title will be "Maintenance of Genomic Stability" and will feature
Richard Kolodner and David Livingston as Keynote Speakers, and also many
others in the fields of DNA repair and the cell cycle. A mailing with
registration and poster abstract information will go out soon.
Please contact Dr. Rodney Nairn (rnairn at mdanderson.org) if you wish to
receive this mail-out information.
5. POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Pittsburgh,
PA; Baltimore, MD; Research Triangle Park, NC; Saskatchewan, Canada;
Bethesda, MD; New Haven, CT; Ann Arbor, MI; Winston-Salem, NC [Note: Check
the list for more Job Opportunities on the DNA Repair Interest Group web
site: http://www.nih.gov:80/sigs/dna-rep/ ]
5.1 HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - POST DOC POSITION-
BETHESDA, MD
We are studying molecular, cellular and clinical abnormalities in patients
with defective DNA repair and possible links of these genes to disease in
the general population. Current emphasis is on xeroderma pigmentosum,
Cockayne syndrome and trichothiodystrophy. A postdoctoral position is
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than
5 years of postdoctoral experience who has knowledge of molecular biology
and DNA repair.
To apply, send CV and bibliography and names (with contact information) of
3 references to:
Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda, MD 20892
TEL: 301-496-9033 FAX: 301-496-8419
e-mail: kraemerk at nih.govhttp://rex.nci.nih.gov/RESEARCH/basic/lmc/khk.htm
NIH is an equal opportunity employer
5.2 TENURE-TRACK FACULTY RESEARCH POSITIONS - UNIVERSITY OF PITTSBURGH
CANCER INSTITUTE
The Molecular and Cellular Oncology Program at the University of
Pittsburgh Cancer Institute (UPCI) is undergoing a major phase of
development, and seeks outstanding applicants for several new positions to
be filled over the next year. An advertisement has recently appeared in
Science (see 1 Feb. issue).
We are searching for investigators whose research efforts are directed
toward defining basic molecular mechanisms of the neoplastic process.
Particular areas of interest for these positions include DNA damage repair
and signaling pathways controlling genome stability, cell cycle control
and growth, apoptosis, analysis of tumorigenesis using functional
genomics, chromatin structure, and analysis of cancer-related pathways in
model organisms.
UPCI is an NCI-designated Comprehensive Cancer Center. It is a vigorous
and cooperative environment with programs encompassing basic,
translational, and clinical cancer research which take advantage of the
University and the strong medical center. In July 2002, the Hillman Cancer
Center will open as a new integrated facility and will accommodate the
research activities for these new positions in the Molecular and Cellular
Oncology Program. More information is available on
http://www.upci.upmc.edu/ and http://www.pitt.edu/~rdwood/links2.htm. The
city of Pittsburgh is a most livable city, with continual scientific
growth and a thriving cultural scene.
Recruitment is focused at the Assistant Professor level, although a
position at a more senior level may be available for an individual with an
established research program. Interested applicants should submit a CV
with summary of research accomplishments, a short research proposal and
the names and contact information for 3 referees to:
Dr. Richard D. Wood
University of Pittsburgh Cancer Institute
S867 Scaife Hall Box 100
3550 Terrace Street,
Pittsburgh,PA 15261.
Documents, preferably as a pdf file, can also be sent by email to R.D.
Wood at: smithp4 at msx.upmc.edu.
The positions are open until filled but applications should be submitted
by 15 March 2002 to assure full consideration.
5.3 POST-DOCTORAL SCIENTIST POSITIONS TO STUDY DNA REPAIR MECHANISMS -
BALTIMORE, MD
1. Post-Doctoral Scientist 1. Biochemistry of Single-Strand Break
Repair. This position will entail the characterization and identification
of proteins that function in the repair of common free radical-induced DNA
damages, most notably 3'-obstructive termini (e.g. 3'-phosphate groups).
Studies will involve purification of proteins from bacteria and
baculovirus, detailed biochemical and kinetic analysis, and examination of
protein-protein cooperativity/associations (including defining the
interactive interfaces). Collaborations with scientists on-site will
permit exploration of the biochemical nature of pathway-pathway
communication. Experience with molecular biology techniques and protein
biochemistry required. Position limited to M.D.s and Ph.D.s with less
than 5 years of post-doctoral experience.
2. Post-Doctoral Scientist 2. Biology of Base Excision Repair. This
position will involve studies to monitor the localization patterns of BER
proteins as a function of cell age, cell cycle stage or environmental
exposure. Studies will also include the evaluation of expressing a
dominant-negative Ape1 protein factor in mammalian cells and/or the
generation of an Ape1 genetic mutant cell line. Mammalian cell culturing
experience is mandatory, as is a sound understanding of molecular biology
techniques. Position limited to M.D.s and Ph.D.s with less than 5 years
of post-doctoral experience.
For further details or to apply for one of these positions, please contact
Dr. David M. Wilson III by mail:
Laboratory of Molecular Gerontology, Box 1
National Institute on Aging, IRP, NIH
5600 Nathan Shock Drive
Baltimore, MD 21224-6825
or by email via Pat Freburger at freburgerp at grc.nia.nih.gov. As part of
the application please include curriculum vitae and three letters of
reference. NIH is an equal opportunity employer.
5.4 POSTDOCTORAL FELLOWSHIP NIEHS, NIH, RESEARCH TRIANGLE PARK, NC
A Molecular Biology Fellowship position is available to investigate the
role of human variation in DNA repair on cancer risk. Studies will examine
the correlation between DNA repair phenotype, repair gene polymorphisms,
and mutation frequency in preneoplastic and normal tissue. Research will
focus on applying phenotypic measures of DNA repair capacity in specimens
from epidemiologic studies of cancer patients and controls. Large
collection of well characterized biological samples are available with
detailed genotypic information. Primary cancer of interest include
bladder, lung, and prostate. Experience with Comet, Host Cell
Reactivation, Chromosomal Break or other measures of DNA repair is
desirable but not essential. This position features opportunities for
interdisciplinary training in the rapidly expanding field of molecular
epidemiology and clinical/translationional studies. Possibilities for
extension into expression array, proteomics (using SELDI) and other
emerging technologies are readily available in core facilities. Excellent
resources, supplies, and opportunities for training and development.
Candidates should have a Ph.D., M.D. or equivalent degree in molecular
biology, cell biology, biochemistry, genetics, or related field. Applicant
must have less than 5 years of postdoctoral research experience. Recent
graduates are encouraged to apply. Salary $30.5-39.5K based on experience
plus health benefits.
Send CV to:
Jack A. Taylor, MD, PhD, Head
Molecular and Genetic Epidemiology Section, MD A3-05
NIEHS, NIH, PO Box 12233
Research Triangle Park, North Carolina 27709E-mail: taylor at niehs.nih.gov
Tel: (919) 541-4631 Fax: (919) 541-2511
5.5 POSTDOCTORAL POSITIONS AT UNIVERSITY OF SASKATCHEWAN, CANADA
Two postdoctoral positions are available immediately. One is to study DNA
postreplication repair and mutagenesis in mammalian cells and in a
transgenic mouse model. The second position is to study molecular
mechanisms of gene regulation in response to DNA damage, using budding
yeast as a model eukaryote.
Candidates with background in biochemistry, cell biology, molecular
biology and genetics are encourage to apply. Salary competitive and is
based on experience. Please send CV and names of three references with
contact information to:
Wei Xiao, Ph.D.
Professor
Department of Microbiology and Immunology
University of Saskatchewan
107 Wiggins Road
Saskatoon, SK, S7N 5E5 Canada
Tel: 306-966-4308
Fax: 306-966-4311
E-mail: wei.xiao at usask.ca
Web site: http://www.usask.ca/medicine/microbio/xiaow/
5.6 DNA DAMAGE, DNA REPAIR, AND NEURODEGENERATION - POST-DOC -BETHESDA, MD
A postdoctoral position is available in the Laboratory of Neurogenetics,
Division of Intramural Clinical and Biological Research,National Institute
on Alcohol Abuse and Alcoholism, National Institutes of Health. We study
the formation and repair of endogenous DNA lesions, and the relationship
of such lesions to neurodegenerative diseases. (See J. Biol Chem 2000
275:22355-62, J Biol Chem. 2001 276:36051-7). Experience with DNA repair
assays, as well as with methods of DNA adduct detection such as
quantitative PCR, LM-PCR, postlabeling, or mass spectrometry is desirable.
Applicants must have a Ph.D. or M.D. degree and less than five years of
postdoctoral training experience. Competitive salary will be commensurate
with relevant research experience. Send CV and bibliography and names
(with contact information) of 3 references to:
P.J. Brooks, Ph.D.
Investigator, Tenure-Track
Laboratory of Neurogenetics
NIAAA NIH
12420 Parklawn Drive, MSC 8110
Bethesda, MD 20892-8110
301 496-7920
301 443-8579 (FAX)
Email pjbrooks at mail.nih.gov <mailto:pjbrooks at mail.nih.gov>
NIH is an Equal Opportunity Employer. Applications from women, minorities,
and persons with disabilities are strongly encouraged. The DICBR/NIAAA is
a
smoke-free environment.
5.7 POST-DOCTORAL FELLOWSHIP - TARGETED MUTAGENESIS -NEW HAVEN, CT
An NIH-funded position is available to study targeted mutagenesis in
epidermal keratinocytes at Yale University. The focus on triplex-mediated
gene targeting and homologous recombination in keratinocytes is a
collaboration between Drs. Peter Glazer and Leonard Milstone. Individuals
who are interested in learning epidermal biology and who have a background
in DNA repair or homologous recombination are particularly suitable
candidates. Applicants must have an MD or PhD and less than 5 years
post-doc experience.
Send CV and three letters of reference to:
Leonard Milstone, MD
Dermatology
Yale University School of Medicine
PO Box 208059
New Haven, CT. 06520-8059
leonard.milstone at yale.edu
or
Peter Glazer, MD, PhD
Therapeutic Radiology
Yale University School of Medicine
PO Box 208059
New Haven, CT. 06520-8059
peter.glazer at yale.edu
5.8 POSTDOCTORAL OPPORTUNITY AT UNIVERSITY OF MICHIGAN, ANN ARBOR
Our laboratory's interest is to gain insight into the basis of chromosomal
rearrangement in cancer by studying the molecular mechanisms of DNA
double-strand break repair. The fellow will be able to choose from several
related project areas, including (1) use of recently developed genomic
approaches to explore the choice between recombination and nonhomologous
end joining (NHEJ), (2) biochemical and genetic characterization of the
polymerase(s), nuclease(s), and other enzymes required for end-processing
during NHEJ, and (3) the molecular basis for repair of
topoisomerase-induced breaks.
Candidates should have a strong background in applied biochemistry,
molecular biology and/or genetics. Experience with yeast would be of
benefit, but is not required. Send a cover letter, CV, and the names of
three references, to:
Thomas E. Wilson, M.D., Ph.D.
Department of Pathology
University of Michigan Medical School
Medical Science I M4214/0602
1301 Catherine Rd.
Ann Arbor, MI 48109-0602
Email: postdoc at tewlab.path.med.umich.edu
Website: http://tewlab.path.med.umich.edu/
5.9 POSTDOC POSITION - WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE,
WINSTON-SALEM, NORTH CAROLINA
Postdoc position is available to investigate the roles of DNA
damage/repair in human cancer risk (prostate, breast, and colon).
Candidate will participate in several ongoing studies with focus on the
functional significance of DNA repair genetic polymorphisms in DNA
damage/repair and cancer susceptibility. Experience with DNA damage/repair
assays or statistics/epidemiology desirable. This position will be
supported by a NIH grant initially and the candidate is eligible to apply
for a postdoc fellowship provided by the training grant of the Department
of Cancer Biology. Candidates should have a Ph.D., M.D., or equivalent
degree in molecular biology, cell biology, biochemistry,
genetics, epidemiology, or related field. Applicant must have less than3
years of postdoctoral experience. Recent graduates are encouraged toapply.
Salary $30K-35K based on experience plus health benefits. Available
immediately.
To apply, send CV and list of three references(with contact information )
to:
Jennifer J. Hu, Ph.D.
Department of Cancer Biology
Wake Forest University School of MedicineMedical Center Blvd.
Winston-Salem, NC 27157
e-mail:jenhu at wfubmc.edu
6. ELECTRONIC CONTACTS:
6.1 Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.
6.2 Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject blank. In the message field, type in: subscribe
DNARepair-L your name
Alternatively, by filling out the form on the website
(http://www.nih.gov:80/sigs/dna-rep/ ) you can both add your name to the
e-mail list and have your name posted on the website. If you want your
name to be listed you can fill out the "Join the SIG" form on the web site
and add your name to the listing of members. If you are not at NIH then
be sure to click the "other" box and then fill in the name of your
institution.
6.3 Archives of these listserve mailings can be found at
http://list.nih.gov/archives/dnarepair-l.html or via links from
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
6.4 I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 825 scientists around the world who are
interested in DNA repair.)
Kenneth H. Kraemer, M.D.
Chief, DNA Repair Section
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda, MD 20892
301-496-9033 FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
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