----------
From: "Kenneth H. Kraemer" <khk at nih.gov>
Reply-To: Ken Kraemer <kraemerk at nih.gov>
Date: Thu, 31 Jan 2002 13:13:40 -0500
To: DNAREPAIR-L at LIST.NIH.GOV
Subject: DNA Repair Interest Group -UPDATE - January 31, 2002
DNA Repair Interest Group -UPDATE - January 31, 2002
1. VIDEOCONFERENCE - Feb 19, 2002 - Dr. Yves Pommier - NCI -
Nucleotide excision repair-dependent cytotoxicity of a novel anticancer
agent, ecteinascidin 743.
2. DNA DAMAGE AND REPAIR PRODUCTS
3. New DNA Repair Journal
4. CONFERENCES -ENVIRONMENTAL MUTAGEN SOCIETY; IUPAC Symposium on
Photochemistry; M.D. Anderson Symposium on Fundamental Cancer Research
5. POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Bethesda, MD;
New Haven, CT; Ann Arbor, MI; Winston-Salem, NC; Worcester, MA; Boston,
MA; Research Triangle Park, NC; Livermore, CA
6. DNA Repair antibodies
7. Electronic Contacts
1.0 DNA REPAIR VIDEOCONFERENCE:
Feb 19, 2002 - Tues 12:30PM - Dr. Yves Pommier - NCI - Nucleotide excision
repair-dependent cytotoxicity of a novel anticancer agent, ecteinascidin
743.
VIDEOCONFERENCE LOCATIONS: Building 45 (NATCHER) Room H, Bethesda, MD
(origin); Building 101 Room B200, NIEHS, Research Triangle Park, NC; State
University of New York, Stony Brook, NY; Room 1E03 GRC Baltimore, MD; MD
Anderson, Smithville, TX; Univ of Kentucky, Lexington, KY; Building 549,
Conference Room A, FCRDC, Frederick, MD; Lawrence Livermore Labs,
Livermore, CA; Univ of Michigan, Ann Arbor; Brookhaven National Labs,
Upton, NY and University of Pittsburgh and live on the internet at
http://videocast.nih.gov
1.1 DNA REPAIR VIDEOCONFERENCE - FUTURE DATES AND VIDEO ARCHIVE
[Note: A larger and more up to date list of future and past
videoconferences can be found on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
1.1.1 FUTURE VIDEOCONFERENCES:
Mar 19, 2002 - Tues 12:30PM - Dr. Alan Tomkinson - Univ of Texas, San
Antonio- Mechanisms of DNA End Joining
Apr 16, 2002 - Tues 12:30PM - Dr. Philip Hanawalt - History of DNA Repair
May 21, 2002 - Tues 12:30PM - Talks by post doctoral fellows
June 18, 2002 - Tues 12:30PM - Dr. David Chen - Lawrence Berkeley National
Lab - Role of DNA-PK in Cellular Responses to DNA damage
1.1.2 VIDEOARCHIVES: INTERNET ACCESS (WORLDWIDE):
Now 39 of these videoconferences have been archived and are available for
viewing at your leisure on the internet. You will need a web browser (with
a high speed link) and free Real Video software. Setup details and access
are available at the NIH videocast website: http://videocast.nih.gov. Go
to Unicast sessions; Past events; DNA Repair Interest Group Sessions.
Note: Technical improvements are made regularly on this site to increase
transmission speeds and ease of access. If you were not successful in
viewing these videos in the past it is worth trying again!
Jan 15, 2002 - Dr. Tom Kunkel- NIEHS - Recent studies of DNA Mismatch
Repair
Dec 18, 2001 - Dr. Richard Wood - Univ of Pittsburgh- Tolerating damaged
DNA
Nov 13, 2001 - Dr. J. Christopher States - University of Louisville-
Cisplatin regulation of XPA expression in ovarian cancer cells [Note:
Posting of this videoconference will be delayed at the request of the
speaker]
Oct 16, 2001 - Dr. Daniel Yarosh - Applied Genetics - Reduction of Skin
Cancer in XP Patients Treated Topically with DNA Repair Enzymes
JUNE 19, 2001 - Dr. James Cleaver -Univ of California, San Francisco, CA -
History of DNA Repair - Mending Human Genes
MAY 15, 2001- Dr. Bill Copeland - Laboratory of Molecular Genetics NIEHS -
Family A DNA polymerases in eukaryotic DNA replication and repair
MAR 20, 2001 - Short talks at 3 sites:
Peter Beernink, LLNL - A Second Divalent Metal Ion in the Active Site of a
New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and
its Implications for the Catalytic Mechanism
Yong Hwan Jin, NIEHS - The 3'-5' Exonuclease of DNA Polymerase d is
Redundant with
5'-flap Endonuclease Rad27/Fen1 for Processing of Okazaki Fragments
Robert M. Brosh, NIA - Molecular Interactions of the Werner Syndrome
Protein
FEB 20, 2001 - Dr. Vilhelm Bohr - LMG, NIA, Baltimore, MD - DNA repair
defects in premature aging disorders
JAN 16, 2001- Dr. Mats Ljungman - Univ of Michigan, Ann Arbor, MI -Stopped
in its tracks - RNA polymerase II as a sensor for DNA damage
Through the miracle of videotape we now have been able to post most of the
DNA Repair Interest Group videoconferences from 1998,1999 and 2000 on the
web site. These include talks by Drs. Bogenhagen, Sutherland, Kunkel,
Stefanini, Hanawalt, Matson, Sharan, Kashlev , Fornace, Anderson, Leadon,
Brooks, McKay, Drotschmann, Chu, Thompson, Woodgate, George, Liu,
Grossman, Essigman, Emmert, Sobol, Glazer, Setlow, Kraemer, Matsumoto,
Wang, and Sung.
2. DNA DAMAGE AND REPAIR PRODUCTS
The inherent chemical instability of DNA renders it vulnerable to damage
by both endogenous and exogenous agents. As such, cells have DNA repair
processes to counteract the deleterious effects of DNA damage and to
maintain genomic integrity. Among these repair processes are direct
repair, base excision repair (BER), nucleotide excision repair (NER),
mismatch repair, and double strand break repair. All of these mechanisms
work in concert with the cell cycle and programmed cell death to maintain
genomic fidelity and integrity for the organism.
R&D Systems now offers a variety of products for use in DNA Damage and
Repair studies. For information on these or other product lines, please
call 1-800-343-7475 or visit our web site at http://www.RnDSystems.com
3. New DNA REPAIR JOURNAL
Dr. Larry Thompson writes:
The DNA Repair section of Mutation Research is now changed into a new
journal, completely separate from Mutation Research. A website explains
the new journal:
http://www.elsevier.com/locate/dnarepair
4. CONFERENCES -ENVIRONMENTAL MUTAGEN SOCIETY; IUPAC Symposium on
Photochemistry; M.D. Anderson Symposium on Fundamental Cancer Research
[Note: A larger and more up-to-date list of conferences can be found on
the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
4.1 ANNUAL MEETING OF THE ENVIRONMENTAL MUTAGEN SOCIETY -
Anchorage, Alaska, 27 April - 2 May, 2002
"FRONTIERS BEYOND THE HUMAN GENOME"
Program Chair: Larry Loeb
The program for the 33rd Annual Meeting of the Environmental Mutagen
Society (EMS) is now available at http://www.ems-us.org/program02.html.
A number of symposia and sessions are devoted to DNA repair. These include
"Double-Stranded Breaks: The Ultimate End Game"
"Complex DNA Lesions: Repair and Mutagenesis"
"When Polymerases Are Arrested, Who Is at Fault, and What Are the
Options?"
Please check out the details of the conference at www.ems-us.org. Click on
"meetings."
Hope to see you there!
David M. DeMarini
President, EMS
demarini.david at epa.gov
4.2 IUPAC Symposium on Photochemistry - Budapest, Hungary, July 14-19,
2002
The home page of the XIXth IUPAC Symposium on Photochemistry is being
updated. You will find all necessary forms and deadlines, including the
form for the submission of abstracts. If you intend to present an oral
contribution, please note the deadline of March 1, 2002. Oral
presentations will be selectedby the International Scientific Committee
(ISC). The home page will be updated from time to time, as needed, so
please check it occasionally.
http://www.photoiupac.hu
Heinz Roth and Jozsef Nyitrai
4.3 55th MD ANDERSON SYMPOSIUM ON FUNDAMENTAL CANCER RESEARCH - HOUSTON,
TX, OCT 15-18, 2002
The title will be "Maintenance of Genomic Stability" and will feature
Richard Kolodner and David Livingston as Keynote Speakers, and also many
others in the fields of DNA repair and the cell cycle. A mailing with
registration and poster abstract information will go out soon.
Please contact Dr. Rodney Nairn (rnairn at mdanderson.org) if you wish to
receive this mail-out information.
5. POST DOC AND EMPLOYMENT OPPORTUNITIES: Bethesda, MD; Bethesda, MD;
New Haven, CT; Ann Arbor, MI; Winston-Salem, NC; Worcester, MA; Boston,
MA; Research Triangle Park, NC; Livermore, CA [Note: Check the list for
more Job Opportunities on the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/ ]
5.1 HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - POST DOC POSITION-
BETHESDA, MD
We are studying molecular, cellular and clinical abnormalities in patients
with defective DNA repair and possible links of these genes to disease in
the general population. Current emphasis is on xeroderma pigmentosum,
Cockayne syndrome and trichothiodystrophy. A postdoctoral position is
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than
5 years of postdoctoral experience who has knowledge of molecular biology
and DNA repair.
To apply, send CV and bibliography and names (with contact information) of
3 references to:
Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda, MD 20892
TEL: 301-496-9033 FAX: 301-496-8419
e-mail: kraemerk at nih.govhttp://rex.nci.nih.gov/RESEARCH/basic/lmc/khk.htm
NIH is an equal opportunity employer
5.2 DNA DAMAGE, DNA REPAIR, AND NEURODEGENERATION - POST-DOC -BETHESDA, MD
A postdoctoral position is available in the Laboratory of Neurogenetics,
Division of Intramural Clinical and Biological Research,National Institute
on Alcohol Abuse and Alcoholism, National Institutes of Health. We study
the formation and repair of endogenous DNA lesions, and the relationship
of such lesions to neurodegenerative diseases. (See J. Biol Chem 2000
275:22355-62, J Biol Chem. 2001 276:36051-7). Experience with DNA repair
assays, as well as with methods of DNA adduct detection such as
quantitative PCR, LM-PCR, postlabeling, or mass spectrometry is desirable.
Applicants must have a Ph.D. or M.D. degree and less than five years of
postdoctoral training experience. Competitive salary will be commensurate
with relevant research experience. Send CV and bibliography and names
(with contact information) of 3 references to:
P.J. Brooks, Ph.D.
Investigator, Tenure-Track
Laboratory of Neurogenetics
NIAAA NIH
12420 Parklawn Drive, MSC 8110
Bethesda, MD 20892-8110
301 496-7920
301 443-8579 (FAX)
Email pjbrooks at mail.nih.gov <mailto:pjbrooks at mail.nih.gov>
NIH is an Equal Opportunity Employer. Applications from women, minorities,
and persons with disabilities are strongly encouraged. The DICBR/NIAAA is
a
smoke-free environment.
5.3 POST-DOCTORAL FELLOWSHIP - TARGETED MUTAGENESIS -NEW HAVEN, CT
An NIH-funded position is available to study targeted mutagenesis in
epidermal keratinocytes at Yale University. The focus on triplex-mediated
gene targeting and homologous recombination in keratinocytes is a
collaboration between Drs. Peter Glazer and Leonard Milstone. Individuals
who are interested in learning epidermal biology and who have a background
in DNA repair or homologous recombination are particularly suitable
candidates. Applicants must have an MD or PhD and less than 5 years
post-doc experience.
Send CV and three letters of reference to:
Leonard Milstone, MD
Dermatology
Yale University School of Medicine
PO Box 208059
New Haven, CT. 06520-8059
leonard.milstone at yale.edu
or
Peter Glazer, MD, PhD
Therapeutic Radiology
Yale University School of Medicine
PO Box 208059
New Haven, CT. 06520-8059
peter.glazer at yale.edu
5.4 POSTDOCTORAL OPPORTUNITY AT UNIVERSITY OF MICHIGAN, ANN ARBOR
Our laboratory's interest is to gain insight into the basis of chromosomal
rearrangement in cancer by studying the molecular mechanisms of DNA
double-strand break repair. The fellow will be able to choose from several
related project areas, including (1) use of recently developed genomic
approaches to explore the choice between recombination and nonhomologous
end joining (NHEJ), (2) biochemical and genetic characterization of the
polymerase(s), nuclease(s), and other enzymes required for end-processing
during NHEJ, and (3) the molecular basis for repair of
topoisomerase-induced breaks.
Candidates should have a strong background in applied biochemistry,
molecular biology and/or genetics. Experience with yeast would be of
benefit, but is not required. Send a cover letter, CV, and the names of
three references, to:
Thomas E. Wilson, M.D., Ph.D.
Department of Pathology
University of Michigan Medical School
Medical Science I M4214/0602
1301 Catherine Rd.
Ann Arbor, MI 48109-0602
Email: postdoc at tewlab.path.med.umich.edu
Website: http://tewlab.path.med.umich.edu/
5.5 POSTDOC POSITION - WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE,
WINSTON-SALEM, NORTH CAROLINA
Postdoc position is available to investigate the roles of DNA
damage/repair in human cancer risk (prostate, breast, and colon).
Candidate will participate in several ongoing studies with focus on the
functional significance of DNA repair genetic polymorphisms in DNA
damage/repair and cancer susceptibility. Experience with DNA damage/repair
assays or statistics/epidemiology desirable. This position will be
supported by a NIH grant initially and the candidate is eligible to apply
for a postdoc fellowship provided by the training grant of the Department
of Cancer Biology. Candidates should have a Ph.D., M.D., or equivalent
degree in molecular biology, cell biology, biochemistry,
genetics, epidemiology, or related field. Applicant must have less than3
years of postdoctoral experience. Recent graduates are encouraged toapply.
Salary $30K-35K based on experience plus health benefits. Available
immediately.
To apply, send CV and list of three references(with contact information )
to:
Jennifer J. Hu, Ph.D.
Department of Cancer Biology
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
e-mail:jenhu at wfubmc.edu
5.6 POSTDOCTORAL POSITION - WORCESTER, MA
A postdoctoral position will be available Spring-Summer 2002 to study
drug-induced recombination in Escherichia coli K-12 (see J. Bacteriol.
182,
463-468; Chemistry and Biology 7, 39-50). Working knowledge of bacterial
genetics desirable but not essential.
Applicants should send a CV and the names of three references to:
martin.marinus at umassmed.edu
or
Dr MG Marinus,
Biochemistry and Molecular Pharmacology,
University of Massachusetts MedicalSchool,
55 Lake Ave,
Worcester MA 01655 USA. (Worcester MA is located 50 km west of Boston).
5.7 POST DOCTORAL POSITION - BOSTON, MA
A postdoctoral position is available to study the molecular basis for DNA
damage-induced mitotic homologous recombination in mammals. Particular
emphasis is on the how the base excision repair pathway modulates cellular
susceptibility to homologous recombination. Current projects are focused
on using cell culture and whole animal models to explore the mechanisms by
which DNA lesions lead to sequence rearrangements. A system for using
fluorescence to monitor homologous recombination events in adult mice has
recently been developed in this laboratory, thus opening exciting
opportunities to study mechanisms by which genetic and environmental
factors induce homologous recombination in mammals.
For more information, please contact:
Bevin P. Engelward, Sc.D.
MIT Division of Bioengineering and Environmental Health
bevin at mit.edu
5.8 POSTDOC RESEARCH OPPORTUNITY - RESEARCH TRIANGLE PARK, NORTH CAROLINA
Molecular Epidemiology of DNA Repair Fellowship position is available to
investigate the role of human variation in DNA repair on cancer risk.
Studies will examine the correlation between repair phenotype and DNA
repair gene polymorphisms and mutation frequency in preneoplastic and
normal tissue and will also focus on applying phenotypic measures of
repair capacity in samples from case-control studies. Experience with Host
Cell Reactivation, Comet, and Chromosomal Break and other repair assays
desirable. This position is within an interdisciplinary training program
with a primary appointment to the Laboratory of Molecular Carcinogenesis
and adjunct appointment in the Epidemiology Branch.Excellent resources,
equipment, supplies, and opportunities for interdisciplinary training and
development are available.
Candidates should have a Ph.D., M.D. or equivalent degree in molecular
biology, cell biology, biochemistry, genetics, or related field. Applicant
must have less than 5 years of postdoctoral research experience. Recent
graduates are encouraged to apply. Salary $30-36.5K based on experience
plus health benefits. Available October 1, 2001.
APPLY TO:
Jack A. Taylor, MD, PhD, Head
Molecular and Genetic Epidemiology Section, MD A3-05
NIEHS, NIH, PO Box 12233
Research Triangle Park, North Carolina 27709
E-mail: taylor at niehs.nih.gov
Tel: (919) 541-4631 Fax: (919) 541-2511
http://dir.niehs.nih.gov/dirlmc/lmcmges.htm
5.9 POSTDOCTORAL POSITIONS IN DNA REPAIR RESEARCH AT LAWRENCE
LIVERMORE NATIONAL LABORATORY, Livermore, California
Several positions for basic mechanistic studies exist in the Biology &
Biotechnology Research Program (BBRP) for recent PhDs (less than 5 years)
in biochemistry, molecular biology/genetics, or related fields.
To construct and characterize knockout mutants in DNA repair pathways,
including homologous recombinational repair, in CHO hamster cells; to
study the role of the Fanconi anemia group G gene in maintaining
chromosome stability by using genetic and biochemical approaches; to
obtain the structure of recombinational repair proteins. Background in DNA
repair preferred. Reply to Larry Thompson at thompson14 at llnl.gov
LLNL offers a challenging environment and competitive salary and benefits.
We are located in the scenic Livermore Valley and have interactions with
DNA repair researchers at UC Berkeley, UC San Francisco, UC Davis, and
Stanford University. LLNL is an equal opportunity employer with a
commitment to workforce diversity.
6. DNA Repair Antibodies
Novus Biologicals, Inc introduces their latest service on obtaining
information on NEW antibodies in the DNA Repair and related fields. To
sign up for this e-mail notification, please visit our web site,
www.novus-biologicals.com.
For more information contact:
Bryan Tinsley
Novus Biologicals, Inc
Telephone: 303-730-1950
Toll-Free: 888-506-6887
Fax: 303-730-1966
7. ELECTRONIC CONTACTS:
7.1 Check out the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
You can find the schedule for future DNA Repair Interest Group
videoconferences and a listing of past videoconferences (with links to the
videoarchive) as well as a current list of JOB OPPORTUNITIES in DNA repair
and MEETING NOTICES.
7.2 Encourage your colleagues who are interested in DNA Repair to
request that they be added to this DNA Repair Interest Group listserve
e-mail list by sending a request by e-mail to: listserv at list.nih.gov
Leave the subject blank. In the message field, type in: subscribe
DNARepair-L your name
Alternatively, by filling out the form on the website you can both
add your name to the e-mail list and have your name posted on the website.
If you want your name to be listed you can fill out the "Join the SIG"
form on the web site and add your name to the listing of members. If you
are not at NIH then be sure to click the "other" box and then fill in the
name of your institution.
7.3 Archives of these listserve mailings can be found at
http://list.nih.gov/archives/dnarepair-l.html
or via links from the DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
7.4 I will be happy to relay information about post-doctoral
positions, jobs and meetings and other information related to DNA Repair.
Please send me an e-mail message (kraemerk at nih.gov) and I will incorporate
it into the next announcement list and post it on the DNA Repair Interest
Group web site: http://www.nih.gov:80/sigs/dna-rep/ .
(This list goes to more than 800 scientists around the world who are
interested in DNA repair.)
Kenneth H. Kraemer, M.D.
Chief, DNA Repair Section
Basic Research Laboratory
National Cancer Institute
Building 37 Room 3E24
Bethesda, MD 20892
301-496-9033 FAX: 301-496-8419
e-mail: kraemerk at nih.gov
DNA Repair Interest Group web site:
http://www.nih.gov:80/sigs/dna-rep/
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