HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - POST-DOCTORAL
FELLOWSHIP - BETHESDA, MD
We are studying molecular, cellular and clinical abnormalities in patients
with defective DNA repair and possible links of these genes to disease in
the general population. Current emphasis is on xeroderma pigmentosum,
Cockayne syndrome and trichothiodystrophy. A postdoctoral position is
available for a talented individual (M.D., Ph.D. or MD-PhD) with less than
5 years of postdoctoral experience who has knowledge of molecular biology
and DNA repair.
To apply, send CV and bibliography and names (with contact information) of
3 references to:
Kenneth H. Kraemer, M.D.
Basic Research Laboratory
National Cancer Institute, NIH
Building 37 Room 3E24
Bethesda, MD 20892
TEL: 301-496-9033 FAX: 301-496-8419
e-mail: kraemerk at nih.govhttp://rex.nci.nih.gov/RESEARCH/basic/lmc/khk.htm
NIH is an equal opportunity employer.
POST-DOCTORAL POSITION- Beckman Research Inst. City of Hope Med. Ctr.
A post-doctoral position is available to study 1) study the
induction of repair enzymes (adaptation) in mammalian cells, 2) study
intracellular competition between classes of adducts for repair capacity,
or 3) Increase the sensitivity of ligation-mediated PCR by purifying DNA
fragments with rare lesions using histidine tagged repair enzymes which
bind lesions in dsDNA but do not cut.
Applicants should send a letter of interest, C.V., and a list of
references, including telephone numbers and e-mail addresses, to the
following address:
Gerald P. Holmquist, Ph.D.
City of Hope-Biology
City of Hope-Biology
1450 E Duarte rd
Duarte, CA 91010
TEL: 626-301-8350:: FAX -1-626-358-7703 gholm at .coh.org
POSTDOCTORAL POSITION IN DNA REPAIR (Medical Research Council,
Radiation & Genome Stability Unit, Harwell, Oxfordshire, UK,
http://www.ragsu.har.mrc.ac.uk)
A position is available in the newly formed Biochemistry Group to
investigate the biochemical, molecular and cellular processes of DNA
repair. Specific studies include defining the repair mechanism for
ionizing radiation-induced DNA damage with a particular focus on the role
of base excision repair proteins. Position is initially for 3 years with
possible extension to 5 years. Informal enquiries welcome to Grigory
Dianov ( g.dianov at har.mrc.ac.uk ).
Please apply by full CV with names of 2 referees to the
Personnel Officer ,
Medical Research Council,
Harwell, Oxfordshire, OX11 0RD, UK.
Tel. 44-1235 834393 or fax 44-1235 834776.
Closing data 18th August. Interviews: early September 2000.
THREE POSTDOCTORAL POSITIONS - JOHNS HOPKINS ONCOLOGY CENTER,
BALTIMORE, MD
Three postdoctoral positions are available immediately to investigate the
molecular and genetic mechanisms of mitochondrial DNA damage, repair and
mutagenesis relevant to cancer (See Singh KK (Editor) Mitochondrial DNA
mutations in aging, disease and cancer, Springer, NY 1998. and Singh KK
etal
Oncogene 18:6641-6646 1999).
1. Mammalian model system:Excellent opportunity for an individual with
experience in mammalian cell culture, DNA transfection, Northern,
Southern, PCR, and general molecular biology techniques.
2. Yeast model system: Excellent opportunity for an individual with
experience in yeast genetics, DNA transformation, PCR, Northern, Southern,
and general molecular biology techniques.
3. Mitochondrial Dysfunction in Breast Cancer: Excellent opportunity for
an individual with experience in mammalian cell culture, DNA
transfection, Northern, Southern, PCR, and general molecular biology
techniques. Candidate for this position should be either US citizen or
permanent resident.
Experience in mitochondrial methods desirable but not necessary.
Please forward/fax curriculum vitae and a brief description of research
experience with a list of three references to:
Keshav K. Singh, Ph.D.
Johns Hopkins Oncology Center
Bunting-Blaustein Cancer Research Building
1650 Orleans Street, Room 1-143
Baltimore, Md 21231-1000
Fax:410-502-7234
E-mail: singhke at jhmi.edu
POST-DOCTORAL POSITION- UNIVERSITY OF CALIFORNIA, DAVIS
A post-doctoral position is available to study the pairing of homologous
chromosomes in the budding yeast Saccharomyces cerevisiae. Projects in the
laboratory are aimed at understanding the mechanism, regulation and roles
of homologous chromosome pairing in meiotic and nonmeiotic cells using
molecular genetic and cytological approaches.
Burgess, S.M. and Kleckner, N. (1999). Collisions between yeast
chromosomes in vivo are governed by three layers of organization. Genes &
Development. 13: 1871-1883.
Burgess, S.M., Kleckner, N. and Weiner, B . (1999). Somatic pairing of
homologs in budding yeast: Existence and modulation. Genes &
Development. 13:1627-41.
Applicants should send a letter of interest, C.V., and a list of
references (including telephone numbers and e-mail addresses) to the
following address:
Sean M. Burgess
Assistant Professor
Section of Molecular and Cellular Biology
One Shields Avenue
University of California, Davis
Davis, CA 95616
E-mail: smburgess at ucdavis.edu TEL: (530) 754-5177
POSTDOCTORAL POSITION - DUARTE, CA
Position available to work in the field of cancer biology, DNA repair and
mutagenesis in mammalian cells. A Ph.D. degree and experience in molecular
biology techniques are required.
Please send CV by email to:
Dr. Gerd P. Pfeifer
Department of Biology
Beckman Research Institute
City of Hope Cancer Center
Duarte, CA 91010. FAX: 626-358-7703.
Email: gpfeifer at coh.org.
POST-DOCTORAL SCIENTIST - LAWRENCE LIVERMORE NATIONAL LABORATORY
Post-doctoral positions available in an interactive laboratory/program
investigating the biochemical, molecular and cellular processes of
mammalian DNA repair. Specific studies include defining the repair
mechanisms for ionizing radiation-induced DNA damage [with a particular
focus on proteins in the base excision or double-strand break
(recombinational) repair pathways], designing structure-function based
inhibitors for radiosensitization, and identifying genetic factors in
human cancer susceptibility. Experience in protein biochemistry or signal
transduction pathways a plus. Positions are for two years, with a
possibility for a third year extension, and begin in late 2000 or early
2001. Salaries start in the mid 30s. Livermore is 45 miles east of San
Francisco.
Please send current CV and letters of recommendation to:
David M.Wilson III,
Lawrence Livermore National Laboratory,
Biology & Biotechnology Research Program, L-441,
7000 East Avenue,
Livermore, CA 94526
e-mail: wilson61 at llnl.gov.
3.8 POSTDOCTORAL FELLOW AT YALE UNIVERSITY:
Position available immediately to study the role of mutagenesis in
cancer. See Proc. Natl. Acad. Sci. USA, 96: 9580-9585. Experience in
tissue cell culture, mutagenesis, and molecular biology is a plus.
Send curriculum vitae, reprints, and the names of three references to :
Dr. Joann B. Sweasy
Department of Therapeutic Radiology
Yale University School of Medicine
333 Cedar Street
PO Box 208040
New Haven, CT 06520
e-mail: joann.sweasy at yale.edu
POST-DOC POSITIONS IN TRANSCRIPTION/DNA REPAIR -GENOTYPE/PHENOTYPE
RELATIONSHIP IN XERODERMA PIGMENTOSUM PATIENTS - FRANCE
Two postdocs position are available to conduct research on:
1) Transcription coupled repair. Studies will use reconstituted
transcription and NER systems and chromatine template. Components will be
isolated from HeLa and XP patients cell lines
2) Regulation of cdk7, a kinase associated with a basal transcription
factor. Four hybrid systems has already identified a battery of proteins
associated with postranscriptional processses as well as with apoptose.
The studies involve techniques in molecular biology, protein expression
and purification, cell culture and enzymatic assays.
Please forward your CV and names and telephone numbers of two references
to:
Jean-Marc Egly
Institut de Biologie Moleculaire et Cellulaire
1 rue Laurent Fries, BP 163,
67400 ILLKIRCH Cedex,
FRANCE
Tel : 33 3 88 65 34 47 Fax : 33 3 88 65 32 01
e-mail:egly at igbmc.u-strasbg.fr
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