Brian Sandle posed some interesting questions about lidocaine metabolism,
dimethylaniline, immunoreactivity, and chronic disease(s) below.
I was wondering about the titers of aniline-albumin, aniline-hemoglobin (or
other protein) antibodies following lidocaine anesthesia. Are they
detectable? Is there an anti-idiotypic response as well?
Aniline is a reasonably good hapten. Perhaps following lidocaine treatment
(and its metabolism) as the primary immune challenge, it seems possible
that aniline (or related compounds) exposure could be common enough of an
environmental factor to perpetuate some level of chronic immune response
(at least in some people).
Chuck
B. Sandle wrote.....
>2,6-Dimethylaniline--hemoglobin adducts from lidocaine in humans.
>: : : :
>: : : : Bryant MS, Simmons HF, Harrell RE, Hinson JA
>: : [...]
>: : : J Autoimmun 1995 Apr;8(2):293-303
>: : :
>: : : Autoantibodies to cryptic epitopes of C-reactive protein and other acute
>: : : phase proteins in the toxic oil syndrome.
>: : :
>: : : Bell SA, Du Clos TW, Khursigara G, Picazo JJ, Rubin RL
>: : :
>: : : Toxic oil syndrome (TOS) was caused by the consumption of rapeseed oil
>: : : contaminated with derivatives of aniline. Many persons who survived the
>: : : acute phase developed a puzzling, multi-year chronic disease
>considered to
>: : : be inflammatory or autoimmune in nature.
>: : [...]
>: : Lidocaine can be immediately a problem for some people. An allergic
>: : reaction occurs. But could there be a longer term problem caused by
>: : aniline metabolites of lidocaine?
>>: Now does Lidocaine cross into to embryonic or fetal blood?
>>: Do lidocaine metabolites pass over?
>>: Does the embryo or fetus have the same risk of allergenicity or aniline
>: toxicity as the mother?
>>: What is more dangerous, amalgam or aniline?
>>Now quite a few people have their amalgam fillings removed and replaced
>with composite. Not all of them get any better. Also a number of people
>report feeling unwell after a dental visit.
>>I wonder if the aniline metabolites from the anaesthetic has been a problem
>for a lot. Besides composite trouble, that is.
Dr. Charles A. Miller III, rellim at mailhost.tcs.tulane.edu
Dept. Environmental Health Sciences, SL29
Tulane-Xavier Center for Bioenvironmental Research and
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Ave.
New Orleans, LA 70112
(504)585-6942, fax (504)584-1726
Bionet.toxicology newsgroup: http://www.bio.net/hypermail/TOXICOLOGY
