If you have not already done so, you might try looking at the following
papers:
Dourson M.L. and J.F. Stara. 1983. Regulatory History and
Experimental Support of Uncertainty (Safety) Factors. Reg. Toxicol.
and Pharmacol. 3:224-238.
Barnes D.G. and M. Dourson. 1988. Reference Dose (RfD):
Description and Use in Health Risk Assessments. Regulatory
Toxicology and Pharmacology. 8:471-486.
Brown, S.L., S.M. Brett, M. Gough, J.V. Rodricks, R.G. Tardiff, and
D Turnbull. 1988. Review of Interspecies Risk Comparisons. Reg.
Toxicol. and Pharmacol. 8:191-206.
Johnson E.M. 1988. Cross-species Extrapolations and the Biologic
Basis for Safety Factor Determinations in Developmental Toxicology.
Reg. Toxicol. and Pharamacol. 8:22-36.
More recent papers may also be of interest to you in addressing this
question. Try a search of PubMed using "uncertainty, interspecies." To name
a few ...
Calabrese EJ, Baldwin LA. 1994. A Toxicological Basis to Derive a
Generic Interspecies Uncertainty Factor.Environ Health Perspect.
102(1):14-7.
Carnes BA, Olshansky SJ, Grahn D. 1998. An interspecies
prediction of the risk of radiation-induced mortality. Radiat Res.
149(5):487-92.
Todd wrote:
> We often use a 10-fold uncertainty factor when considering the
> intraspecies variability in reactions to a particular chemical. I am
> currently interested in looking at cases where that 10-fold factor may
> understate the true variability in the population. I would be greatly
> appreciative if somebody could either give me examples or point me in the
> direction of a good resource to find examples where this may be the case.
> Human variation in reactions to Prozac would be one example. Again, I'd
> appreciate any help that you could lend. Thank you very much!
>> Todd
--
James S. Smith, Jr., Ph.D.
President & Toxicologist
OAK CREEK, Inc.
Toxicology & Risk Assessment Consulting
RR 3 Box 246B
Route 22
Gorham, Maine 04038-9428
Voice : 207.929.6375
Facsimile: 207.929.6474
E-mail : jssmith at oak-creek.net
WWW : http://www.oak-creek.net
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