Intraspecies Variability

James Stanley Smith, Jr., Ph.D. jssmith at oak-creek.net
Mon May 17 13:06:32 EST 1999

If you have not already done so, you might try looking at the following

     Dourson M.L. and J.F. Stara.  1983.  Regulatory History and
     Experimental Support of Uncertainty (Safety) Factors. Reg. Toxicol.
     and Pharmacol. 3:224-238.

     Barnes D.G. and M. Dourson.  1988.  Reference Dose (RfD):
     Description and Use in Health Risk Assessments.  Regulatory
     Toxicology and Pharmacology. 8:471-486.

     Brown, S.L., S.M. Brett, M. Gough, J.V. Rodricks, R.G. Tardiff, and
     D Turnbull.  1988.  Review of Interspecies Risk Comparisons. Reg.
     Toxicol. and Pharmacol. 8:191-206.

     Johnson E.M.  1988.  Cross-species Extrapolations and the Biologic
     Basis for Safety Factor Determinations in Developmental Toxicology.
     Reg. Toxicol. and Pharamacol. 8:22-36.

More recent papers may also be of interest to you in addressing this
question.  Try a search of PubMed using "uncertainty, interspecies."  To name
a few ...

     Calabrese EJ, Baldwin LA.  1994.  A Toxicological Basis to Derive a
     Generic Interspecies Uncertainty Factor.Environ Health Perspect.

     Carnes BA, Olshansky SJ, Grahn D.  1998.  An interspecies
     prediction of the risk of radiation-induced mortality. Radiat Res.

Todd wrote:

> We often use a 10-fold uncertainty factor when considering the
> intraspecies variability in reactions to a particular chemical.  I am
> currently interested in looking at cases where that 10-fold factor may
> understate the true variability in the population.  I would be greatly
> appreciative if somebody could either give me examples or point me in the
> direction of a good resource to find examples where this may be the case.
> Human variation in reactions to Prozac would be one example.  Again, I'd
> appreciate any help that you could lend.  Thank you very much!
> Todd


James S. Smith, Jr., Ph.D.
President & Toxicologist

Toxicology & Risk Assessment Consulting
     RR 3  Box 246B
     Route 22
     Gorham, Maine  04038-9428

     Voice      : 207.929.6375
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     E-mail     : jssmith at oak-creek.net
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