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Post-Doctoral Position Available

Stjasmpa stjasmpa at aol.com
Fri Mar 7 23:32:12 EST 1997

Post-Doctoral Position is available at the University of North Carolina at
Chapel Hill, through the Curriculum in Toxicology headed by Dr. David

Title:  Mechanisms of Age-Related Neurotoxicity to Anticholinesterase

Project Description:  It is well-known that young animals are more
sensitive to the toxic effects of many anticholinesterase pesticides (both
organophophates and carbamates) than adults.  Our earlier research
indicates that this increased sensitivity in the young is due, in part, to
their immature detoxification systems.  This research is based on studies
using only a small number of pesticides.  It is extremely important to
determine, especially in a risk assessment paradigm, if this observation
can be extrapolated to other anticholinesterase pesticides using both
biochemical and pharmacokinetic endpoints.  Our hypothesis is that the
compounds which exhibit a large age-related difference in toxicity will be
those which are detoxified mainily through the carboxylesterase and
phosphotriesterase pathways, but this remains to be tested with other
anticholinesterase pesticides. 
Qualifications: This position requires a PhD in biochemistry, toxicology,
neuroscience or related field preferably with experience with
anticholinesterase pesticides and/or developmental studies.
If you are interested in this position or have any questions, please
 Dr. Stephanie Padilla, Neurotoxicology Division (MD-74B), US
Environmental Protection Agency, Research Triangle Park, NC. Phone: (919)
541-3956 or Email; Stjasmpa at aol.com

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