Hi Andrei,
Cycloheximide inhibits the peptidyl transferase activity of the 60S
ribosomal subunit, thus blocking the elongation step of protein synthesis.
It is specific for eukaryotic ribosomes--does not affect prokaryotic,
mitochondrial and chloroplast ribosomes.
For a reference see L.Stryer's "Biochemistry" 2nd. ed.(1981) p.662, or
several other molecular, cellular or biochemical texts.
Best of results,
Chuck
Dr. Charles A. Miller, rellim at mailhost.tcs.tulane.edu
Founder, Bionet.toxicology news group:
http://www.bio.net/hypermail/TOXICOLOGY
Dept. Environmental Health Sciences, SL29
Room 374, Center for Bioenvironmental Research
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Ave.
New Orleans, LA 70112
(504)585-6942
