TENTATIVE MEETING OUTLINE
BIOMARKERS, THE GENOME & THE INDIVIDUAL---
WORKPLACE AND MEDICAL IMPLICATIONS OF A RAPIDLY EVOLVING
TECHNOLOGY
Charleston, South Carolina
May 4-8, 1997
SUNDAY MAY 4 (The Francis Marion Hotel, Charleston)
4-7 PM Registration
7 PM Keynote address: Dr. Joshua Lederberg* (Nobel Laureate)
8 PM Reception
____________________
MONDAY MAY 5 (Physicians Memorial Auditorium-The College of Charleston)
SECTION: INTRODUCTION AND BACKGROUND
Session Chairman: Dr. Lawrence Mohr*, MUSC
8:20 AM Special Announcements
8:30 AM Introduction and Goals (Dr. Lawrence Mohr*, MUSC)
8:45 AM What is a Valid Biomarker ? (Dr. Paul Schulte*, NIOSH)
9:05 AM Historical Perspectives (Dr. Michael Gochfeld*, EOSHI)
9:25 AM Laboratory Perspectives (Dr. Rogene Henderson*, ITRI)
9:45 AM Panel Discussion: (Chair: Dr. Carol Henry*, DOE)
10:15 AM COFFEE BREAK
10:45 AM Clinical Perspectives (Dr. Robert McCunney*, MIT)
11:05 AM Ethical Perspectives (Dr. Tom Murray*, Case Western)
11:25 AM Public Policy and Costs (Dr. Bernard Goldstein*, EOSHI)
11:45 AM Panel Discussion: (Chair: Dr. Paul Schulte*, NIOSH)
12:15 PM LUNCH BREAK
SECTION: TECHNOLOGIES FOR MEASURING PRIOR EXPOSURES
Session Chairman: Dr. Mort Mendelsohn*, LLNL
1:30 PM Technical Basis for ESR dosimetry (Dr. Marc Desrosiers*, NIST)
1:50 PM Validation of ESR in the Atomic Bomb Survivors Studies (Dr.
Nori Nakamura*, RERF, Japan)
2:10 PM X-ray Fluorescence (Dr. Howard Hu*, Harvard)
2:30 PM Panel Discussion: (Chair: Dr. Dieter Regulla*, GSF, Munich,
Germany)
3:00 PM COFFEE BREAK
3:30 PM Stable Chromosomal Aberrations (Dr. Jim Tucker*, LLNL)
3:50 PM Immune Biomarkers (Dr. Bob Vogt*, CDC)
4:10 PM Isotopic Ratios (Dr. Joseph Graziano*, Columbia)
4:30 PM Panel Discussion: (Chair: Dr. Bernard Goldstein*, EOSHI)
SECTION: STORAGE OF DNA SAMPLES
Session Chairman: Dr. Mark Rothstein*, U. of Houston
5:00 PM Large Scale Genomic Tagging at DOD (Dr. Victor Weedn*, AFIP)
5:20 PM Issues Related to the Re-analysis of Stored Samples (Dr. Ellen
Clayton*, Vanderbilt Medical School)
5:40 PM Panel Discussion: (Chair: Dr. Eula Bingham*, U. of Cincinnati)
____________________
TUESDAY MAY 6 (Physicians Memorial Auditorium-The College of Charleston)
SECTION: TECHNOLOGIES FOR MEASURING RECENT EXPOSURES
Session Chairman: Dr. Richard Albertini*, U. of Vermont
8:20 AM Special Announcements
8:30 AM Volatile Chemicals and the E2R Monitor (Dr. Karla Thrall*, PNL)
8:50 AM Tubular Proteinurea (Dr. Richard Wudeen*, New Jersey)
9:10 AM DNA Adducts (Dr. Kari Hemminki*, Karolinska, Sweden)
9:30 AM Panel Discussion: (Chair: Dr. Leopold Miksche*, Bayer AG,
Germany)
10:00 AM COFFEE BREAK
10:30 AM DNA Adducts using Accelerator Mass Spec (Dr. Ken Turtletaub*,
LLNL)
10:50 AM Protein/haemoglobin Adducts for TCE exposure (Dr. David
McMillan*, MUSC)
11:10 AM Panel Discussion: (Chair: Dr. Mort Mendelsohn*, LLNL)
SECTION: BIOMARKERS OF METABOLIC SUSCEPTIBILITY
Session Chairman: Dr. Paul Brandt-Rauf*, Columbia
11:30 AM P 450 and Chemical Metabolism (Dr. Peter Shields*, NCI)
11:50 PM Acetylation-Related Susceptibilities of Metabolism (Dr. F.
Kadlubar*, NCTR)
12:10 PM Glutathione S-transferase (Dr. Brian Ketterer*, UK)
12:30 PM Panel Discussion: (Chair: Dr. Roger McClellan, CIIT)
1:00-2:00 PM LUNCH BREAK
SECTION: GENOMICS AND TECHNOLOGY DEVELOPMENTS
Session Chairman: Dr. Lee Hood*, U. of Washington
2:00 PM Scientific Basis of Genomic Technologies (Dr. Lee Hood*, U. of
Washington)
2:20 PM High Density DNA Chip Arrays (Dr. Rob Lipshutz*, Affymetrix)
2:40 PM mRNA and the Analysis of Expressed Genes (David Botstein,
Stanford)
3:00 PM Panel Discussion: (Chair: Dr. Marvin Frazier*, DOE)
3:30 PM COFFEE BREAK
4:00 PM Lab-on-a-chip (Dr. Lawrence A. Bock, Caliper Technologies)
4:20 PM Mass Spectra DNA Tags for Multiplex Sequencing (Dr. George Church,
Harvard)
4:40 PM Biomarker Potential of PCR (Dr. Glen Evans*, U. of Texas)
5:00 PM Panel Discussion: (Chair: Dr. Elbert Branscomb*, LLNL)
____________________
7-9:00 PM POSTERS AND DISPLAYS (Cash Bar) -The Francis Marion Hotel
Progress in Diagnostics Kit Technology for Screening for Susceptibility:
o Large pharmaceutical companies (Bayer AG*, Glaxo Wellcome, Smith-
Kline, Merck, Pfizer)
o Other companies: Monsanto, Sequana Therapeutics, Nanogen, Hyseq,
Pharmacia Biotech, Vysis, Amgen, etc.
____________________
WEDNESDAY MAY 7 (Physicians Memorial Auditorium-The College of Charleston)
SECTION: PRACTICAL APPLICATIONS OF BIOMARKERS
Session Chairman: Dr. Barry Johnson*, Director, ATSDR
8:20 AM Special Announcements
8:30 AM Practical Uses of Biomarkers in Population Studies (Dr. Geoffrey
Howe*, Columbia)
8:50 AM Beryllium Biomarkers (Dr. Lee Newman*, National Jewish)
9:10 AM Biomarkers for Aflatoxin (Dr. Regina Santella*, Columbia)
9:30 AM Panel Discussion (Chair: Dr. Robert McCunney* MIT)
10:00 AM COFFEE BREAK
10:30 AM Biomarkers and Models of Radiation Exposure (Dr. Mort
Mendelsohn*, LLNL)
10:50 AM Biomarker Calibration for Estimating Risk (Dr. Leopold Miksche*,
Bayer AG, Germany)
11:10 AM Biomarkers of Pulmonary Toxicity (Dr. Alfred Bernard*, Louvain,
Belgium)
11:30 AM Biomarkers of Reproductive Toxicity (Dr. Don Mattison*, U. of
Pittsburgh)
11:50 AM Panel Discussion (Chair: Dr. Paul Seligman*, DOE)
12:30-1:30 PM LUNCH BREAK
SECTION: PRACTICAL APPLICATIONS OF BIOMARKERS (Cont.)
Session Chairman: Dr. Eula Bingham*, U. of Cincinnati
1:30 PM Mutant Oncoprotein Biomarkers in Chemical Carcinogenesis
(Dr. Paul Brandt-Rauf*, Columbia)
1:50 PM Benzene Metabolites and Benzene Chromosomal Biomarkers
(Dr. Martyn Smith, Berkeley)
2:10 PM Somatic Mutations (Dr. Richard Albertini*, U. of Vermont)
2:30 PM Panel Discussion (Chair: Dr. Dale Hattis*, Clark U.)
3:00 PM COFFEE BREAK
3:30 PM Cotinine as a Biomarker of Smoke Exposure (Dr. Linda Youngman*,
Oxford, UK)
3:50 PM Ethnic Variation and Genetic Susceptibility: G6PD (Dr. David
Jollow*, MUSC)
4:10 PM Breast Cancer Screening and Ethnic Variation (David Goldgar,
IARC, France)
4:30 PM Panel Discussion (Chair: Dr. Carol Redmond*, MUSC)
____________________
THURSDAY MAY 8 (Physicians Memorial Auditorium-The College of Charleston)
SECTION: ETHICAL CONSIDERATIONS
Session Chairman: Dr. Charles Epstein, UCSF
8:20 AM Special Announcements
8:30 AM Ethical Issues (Dr. Charles Epstein, UCSF)
8:50 AM Government Uses of Genetic Information (Dr. Barry Johnson*,
ATSDR)
9:10 AM The Uses of Genetics in the Workplace (Dr. Eula Bingham*,
U. of Cincinnati)
9:30 AM Employers Perspective (Dr. Joe Cannola, Mobil Corporation)
9:50 AM COFFEE BREAK
10:20 AM Non-Medical Uses of Genetic Information (Mark Rothstein*,
U. of Houston)
10:50 AM JUDICIAL PANEL
Biomarkers, Scientific Validity and the Judicial Process
(The Hon. Richard A. Levie*, Deputy Presiding Judge, Civil
Division, Superior Court of the District of Columbia,
The Hon. Thomas S. Ellis, III*, Judge, United State District
Court for the District of Eastern Virginia, and Dr. Franklin
Zweig*, President, EINSHAC)
11:30 AM GENERAL DISCUSSION
Panel: Drs. Charles Epstein, Barry Johnson*, Larry Mohr*,
Mort Mendelsohn*, Carol Henry*, Judges Richard Levie*,
and Thomas Ellis*.
12:30 Closing remarks (Dr. Lawrence Mohr*, MUSC)
____________________
MEETING ADJOURNS
* Confirmed as of 02/05/97
HOTELS
May is peak tourist season in Charleston, SC and we advise you to make your
room reservations as early as possible. To receive special rates, please
contact one of the following hotels on or before April 1, 1997, and refer to
the MUSC BIOMARKER CONFERENCE room block. Please add 12% tax to these hotel
room rates.
Francis Marion Hotel: $109.00 per night (803) 722-0600
(Please inform reservationist if you are a federal government employee for
a discounted room rate. A limited number of these rooms are available on a
first call-first serve basis.)
Quality Inn: $74.00 per night (803) 722-3391
Hampton Inn: $89.00 per night (803) 723-4000
Hawthorn Suites Hotel: $115.00 per night (803) 577-2644
To receive a full registration packet, please call 1-800-277-3239 or fill
out the form below and fax to Jill Yarnall at 1-803-727-6464 or mail to:
Biomarker Conference
Medical University of South Carolina
Environmental Hazards Assessment Program
156 Rutledge Avenue
Charleston, South Carolina 29403
Registration information is available on the Internet through our website
www.ehap.musc.edu
