Does anyone know if trioctanoin affects tissue absorption of DMBA ?
We did a study in the early 1980's using DMBA dissolved in corn
oil administered by gavage to (BALB/c x VY)F1 female mice. This
resulted in a 30-40% mammary tumor incidence (0% in untreated
We have just completed another study using the same protocol and
animals as above but used trioctanoin (instead of corn oil) as a
carrier for the DMBA. We have found extremely few mammary tumors,
but instead quite a few lung tumors.
Any suggestions as to possible reasons/causes for this
discrepancy in the response to DMBA would be most welcome
George L. Wolff
Tel: (501) 543-7522
FAX: (501) 543-7635/7662
3900 NCTR Road
Jefferson, AR 72079-9502