I am looking for expert opinions on the value of in-vitro experiments vs
in-vivo radiolabeled PK studies for determining the rate of skin
permeation of chemicals. I am particularly interested in organic solvents
such as DMSO, which is thought to have a high rate of dermal permeation.
Despite the commonly held belief in scientific circles that DMSO "flies
through the skin" I have been unable to find a reliable PK study to
confirm this. I am skeptical of in vitro studies which tend to use either
cadaver skin or live epidermis.
If you have any specific PK data on DMSO or comparisons between in-vitro
and in-vivo Kp values for the same chemical, please let me know...
Thank you in advance for your help...