In article <CMM-RU.1.4.821213125.ahstern at eohsi.rutgers.edu>,
ahstern at EOHSI.RUTGERS.EDU (Alan Stern) writes:
>>It seems intuitive to me that it should be possible to observe reversal
of
>the classic systemic dose-response relationship at elevated doses, at
least
>for some target organs/systems,[snip] Is anyone aware of
>published references which could provide support for such a toxicologic
>phenomenon?
>
The dose-response curve for tricyclic anti-depressants may be applicable
here.
Christopher E. Jones, PhD
