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reversal of dose-response

C3J5 c3j5 at aol.com
Wed Jan 10 06:21:03 EST 1996


In article <CMM-RU.1.4.821213125.ahstern at eohsi.rutgers.edu>,
ahstern at EOHSI.RUTGERS.EDU (Alan Stern) writes:
>
>It seems intuitive to me that it should be possible to observe reversal
of
>the classic systemic dose-response relationship at elevated doses, at
least
>for some target organs/systems,[snip]  Is anyone aware of
>published references which could provide support for such a toxicologic
>phenomenon?
>

The dose-response curve for tricyclic anti-depressants may be applicable
here.

Christopher E. Jones, PhD



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