rellim at MAILHOST.TCS.TULANE.EDU (Chuck Miller) wrote:
>In his previous post Jack Budny asked the question:
>>>Should a criteria for an animal model for toxicology be that the time-course
>>and characteristics of the toxicologically-induced
>>disease state resemble, replicate or be identical to the toxicant-induced
>>disease condition in humans?
>>I think that if toxicological effects seen in the model system RESEMBLES
>the effects seen in the human system it is sufficient.
>>The reason I say this is that toxicological responses AMONG HUMANS are
>themselves quite variable. An old toxicologist friend used to always remind
>me that "humans are the greatest mongrels". Thus there may not be an exact
>or correct human toxicological response for the animal model to mimic. For
>example, consider how genetic polymorphisms in N-acetyltransferases,
>glutathione-S-transferases
>and P450s affect metabolic activation/detoxification and disesase
>processes. What animal system CAN provide an exact model for a highly
>varied human population?
>>Also-----I say that "RESEMBLES is close enough" because it is a good week
>in the lab when my model is even in the ballpark in estimating what I
>assume to be "the relevant" human toxicological response! : > )
>>Chuck
>>>Dr. Charles A. Miller, rellim at mailhost.tcs.tulane.edu>Bionet.toxicology Discussion Leader
>Dept. Environmental Health Sciences
>Rm. 374, Center for Bioenvironmental Research
>School of Public Health and Tropical Medicine
>Tulane University Medical Center
>1430 Tulane Ave. Box SL29
>New Orleans, LA 70112
>Ph. 504-585-6942, Fx. 504-585-6939
>>>>>>
Along with your "old friend toxicologist" I believe it was either Arnold
Lehman or R. T. Williams said in responding to a discourse on a specific
human metabolism study, "Which human?"
John A. Budny
jabudny at earthlink.net
