p.whitehead at dial.pipex.com (Paul Whitehead) wrote:
>jabudny at EARTHLINK.NET ("John A. Budny") wrote:
>>>Should a criteria for an animal model for toxicology be that the time-course
>>and characteristics of the toxicologically-induced
>>disease state resemble, replicate or be identical to the toxicant-induced
>>disease condition in humans?
>>Clearly we have to distinguish between toxicant induced disease and
>vector induced disease. Many diseases are species specific, cf your
>comment re tuberculosis, and pharmacologists have different models,
>often isolated tissues, to study efficacy and pharmacodynamics.
>>>>Paul Whitehead BSc CBiol MIBiol DABT
>United Kingdom
>e-mail p.whitehead at dial.pipex.com>
Paul,
See George Wolf's comments that would seem to imply the opposite i.e. the
distinction between vector mediated disease and toxicant mediated
disease, according to George are the same - maybe I shouldn't speak for
George.
John A. Budny
jabudny at earthlink.net
