GWOLFF at NCTR.FDA.GOV ("George L. Wolff") wrote:
>I agree with Chuck Miller's post re "resemblance" rather than
>"identity" of animal models and their supposed human counterparts.
>My question always is "Which human" when supposed relevance of an
>animal model to humans in general is mentioned.
>
Makes sense. Sounds like George and Chuck have had experience in the
real world of toxicology. "Wouldn't it be nice if all models were
identical" Get a life Jack! It does not work that way. Budny's First
Law of Biology: "Mother Nature has a mind of her own."
I agree with both of you. Now what I believe we have settled or at least
until someone violently disagrees with the three of us, time-course of
the disease (toxicant-induced because Paul may disagree that toxicant
and vector diseases may be different)is a consideration that should be
taken seriously without the burdensome requirement that the time-course
be identical. Is that agreeable to one and all?
Jack Budny
jabudny at earthlink.net
