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[Protein-analysis] Re: protein engineering

kaj.stenberg at helsinki.fi.invalid kaj.stenberg at helsinki.fi.invalid
Sun Feb 12 06:31:14 EST 2006

mattia <mattia.pedotti at uninsubria.it> wrote:
> Having a protein with Known structure, have someone a general idea
> about how many aminoacids (percent) you can change without altering the
> protein structure? Do you have any reference about this problem?
> Thank you!

Comparing homologous proteins often show detectable structural
similiraty down to some 25% sequence homology. Judging from that one
could argue that some 75% can be changed. On the other hand even one
change has been known to alter the structure.


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