1 : Pharmazie 1999 Jun;54(6):452-6 Related Articles, Books
Aspects of the antimicrobial efficacy of grapefruit seed extract and
its relation to preservative substances contained.
von Woedtke T, Schluter B, Pflegel P, Lindequist U, Julich WD
Institute of Pharmacy, Ernst Moritz Arndt University, Greifswald,
The antimicrobial efficacy as well as the content of preservative
agents of six commercially available grapefruit seed extracts were
examined. Five of the six extracts showed a high growth inhibiting
activity against the test germs Bacillus subtilis SBUG 14, Micrococcus
flavus SBUG 16, Staphylococcus aureus SBUG 11, Serratia marcescens SBUG
9, Escherichia coli SBUG 17, Proteus mirabilis SBUG 47, and Candida
maltosa SBUG 700. In all of the antimicrobial active grapefruit seed
extracts, the preservative benzethonium chloride was detected by thin
layer chromatography. Additionally, three extracts contained the
preserving substances triclosan and methyl parabene. In only one of the
grapefruit seed extracts tested no preservative agent was found.
However, with this extract as well as with several self-made extracts
from seed and juiceless pulp of grapefruits (Citrus paradisi) no
antimicrobial activity could be detected (standard serial broth
dilution assay, agar diffusion test). Thus, it is concluded that the
potent as well as nearly universal antimicrobial activity being
attributed to grapefruit seed extract is merely due to the synthetic
preservative agents contained within. Natural products with
antimicrobial activity do not appear to be present.
PMID: 10399191, UI: 99327390
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