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Rat Antibody Isotype Levels?

Rick Bungiro Richard_Bungiro at brown.edu
Fri Jun 20 14:02:33 EST 1997


Hi folks!

I have recently been immunizing rats with S. mansoni antigens and
evaluating the isotype distribution of the Ag-specific antibodies
produced.  I got to thinking that it might be good to know the normal
level of each isotype (e.g. IgM, IgG1, IgG2a, etc.) in rat serum, but I
have been unable to locate this information.  I have tried various
immunology textbooks (where info is readily available for mouse and human
antibodies), Medline searches, asking a D.V.M., etc.  About the best I
could find was info on the total concentration of gamma globulin in rat
serum - not quite specific enough.

Could anybody out there point me to a reference?

Rick Bungiro



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