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Filarial Genome Project - Research Positions Available

Mark Blaxter mark.blaxter at ed.ac.uk
Tue Jul 30 11:18:25 EST 1996

          ***   AVAILABLE IMMEDIATELY   ***


          ** *** ** TWO POSITIONS ** *** **

           A global project is underway...
            to identify most of the genes
        and to construct a physical genome map
of the human filarial nematode parasite _Brugia_malayi_.

Filarial nematodes infect over 100 milion people worldwide and cause the
debilitating disease of elephantiasis. There is need for both new
anti-filarial drugs and for a protective vaccine. Filarial research is
fortunate that a small freeliving nematode, _Caenorhabditis_elegans_ has
been chosen for in depth genome analysis: _C._elegans_ offers both tested
methods and an amazing comparator for _Brugia_.

TWO positions are available IMMEDIATELY to work on an UK MRC-funded, 3 year
project, based in Edinburgh, Scotland.

** POST ONE ** will have primary responsibility for an expressed sequence
tag (EST) analysis of _Brugia_ genes from several stage-specific cDNA
libraries. The goal is to identify new drug targets and vaccine candidates.
Selected genes-of-interest will be studied in detail (expression analysis,
protein level). The EST analysis will be carried out in close collaboration
with the _C._elegans_ genome researchers at the Sanger Centre, Hinxton,
This position would probably suit a recent PhD graduate (salary 14,500 to
16,000 UK pounds).

** POST TWO ** will be responsible for the construction of a physical map
for _Brugia_ using a bacterial artifical chromosome library and sequenced
tagged site and end-probe markers. The map will be used to investigate
conservation of expression patterns and synteny with the genome of
_C._elegans_: again, there will be close collaboration with the Sanger
Centre in generation and analysis of the data.
This position would probably suit a postdoctoral researcher with interests
in genome analysis (salary 15,000 to 17,300 UK pounds).

No prior experience with _Brugia_, parasites or nematodes is necessary:
just a keen sense of the timeliness of genome approaches to biological
problems, and an eye for the larger goals. Molecular biology, computer
analysis of sequence data, genome experience an advantage.

The project is part of the global initiative sponsored by the World Health
Organisation with participating labs in Africa, India and the USA as well
as Edinburgh. The Edinburgh lab is well funded and has active research
interests in _C._elegans_ and parasitic nematode genetics and biology. We
share facilities with a large _Brugia_ immunology and molecular biology lab
(Prof. RM Maizels).

              See the world wide web at


                   for more details.


******   Dr. Mark Blaxter   Mark.Blaxter at ed.ac.uk   ******

****** *** ***    phone +44 131 650 6760    *** *** ******
****** *** ***    fax   +44 131 650 5450    *** *** ******

***  ICAPB, University of Edinburgh, King's Buildings, ***
***               Edinburgh, UK EH9 3JT                ***

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