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Worm Postdoc

Jim McCarter mccarter at genetics.wustl.edu
Wed Sep 13 22:45:20 EST 1995

C. elegans Postdoctoral Fellowship

	A postdoctoral position is available in our lab to study cell cycle 
regulation and germ/soma interactions affecting the C. elegans oocyte.  
We have recently taken a cell biological and genetic approach to 
understanding how the oocyte controls its cell cycle for maturation and 
how it communicates with the myoepithelial somatic gonad to be expelled 
at ovulation.  We have defined the events involved by time lapse 
microscopy and isolated a class of mutants which are defective in 
ovulation.  Current projects include: isolation of mutants defective in 
oocyte cell cycle regulation (maturation), and molecular 
characterization of new mutants.  More details available upon request.  
The lab has extensive experience in C. elegans germline biology and 
genetics.  See:

	Jones and Schedl.  1995.  Mutations in gld-1, a female germ 
cell-specific tumor suppressor gene in C. elegans, affect a conserved 
domain also found in Src-associated protein Sam68.  Genes and 
Development, 9:1491.
	Francis, Barton, Kimble, and Schedl.  1995.  gld-1, a tumor suppressor 
gene required for oocyte development in C. elegans.  Genetics, 139:579.
	Francis, Maine, Schedl. 1995.  Analysis of the multiple roles of gld-1 
in germline development: interactions with the sex determination cascade 
and the glp-1 signaling pathway.  Genetics, 139:607.
	Clifford, Francis, and Schedl.  1994.  Somatic control of germ cell 
development in C. elegans.  Seminars in Developmental Biology, 5:21.

	We are looking for an individual with genetic, cell biological, or 
molecular training and a strong interest in the cell cycle or cell-cell 
communication.  Support can be provided by an existing grant and the 
position is available immediately.

	Please send inquiries to:

	Dr. Tim Schedl
	Department of Genetics, Box 8232
	Washington University School of Medicine
	4566 Scott Ave., St. Louis, MO 63110, USA
	office: (314) 362-6162
	Fax: (314) 362-7855
	ts at genetics.wustl.edu

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