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[Neuroscience] Re: Initial LTD/LTP phase

Bill via neur-sci%40net.bio.net (by connelly.bill from gmail.com)
Sun Jul 25 18:23:09 EST 2010

Hi Andreas,

LTD is a bit more complex that LTP, and it can really depend on the
exact area of stimulation, and the exact protocol.

There are a large number of reviews on this subject. The most recent
one that springs to mind is:

Nat Rev Neurosci. 2010 Jul;11(7):459-73.
Long-term depression in the CNS.
Collingridge GL, Peineau S, Howland JG, Wang YT.

However, I am confident is saying that the effect from 5-15 minutes is
completely unrelated to vesicle depletion. However, it may involve
retrograde messengers like endocannabinoids, NO etc.. but it can also
be related to postsynaptic changes

On Jul 22, 1:03 am, Andreas Görlich <goerl... from physik.uni-kl.de> wrote:
> I¹m sorry, but I couldn¹t find any papers/reviews explaining what happens in
> the initial phase after LTD/LTP stimulation (CA1)? A standard LTD protocol
> leads initially  to a depression of about let¹s say 70% declining in the
> next 5 to 15 Minutes to 30% (steady state phase). What happens during the
> first few minutes after LTD (LTP) induction? Is it a presynaptic effect
> (depletion of the presynapse) or a postsynaptic effect (dephosphorylation of
> AMPARs) or both? Can you suggest any papers on this topic?
> Thanks
> Andreas

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