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[Neuroscience] Re: Dendritic spine and Synaptic bouton content

r norman via neur-sci%40net.bio.net (by r_s_norman from _comcast.net)
Wed Feb 21 10:43:28 EST 2007


On 21 Feb 2007 03:22:14 -0800, Cervellone from gmail.com wrote:

>I think i will overuse all your mighty brains for a little while
>longer :-)
>
>After reviding my opinion on synapses and dendrites as static shells i
>wanted to know whether there are mitochondria in both, synapses and
>Dendrites. In fact they'd better be with all the atp dependent
>processes but how do they get there? It should be difficult to attach
>a Mitochondrion to anterograde transport and squeeze it through the
>axon.
>

Presynaptic terminals indeed contain mitochondria.  A paper describing
their significance is  "Synaptic mitochondria are critical for
mobilization of reserve pool vesicles at Drosophila neuromuscular
junctions." by P Verstreken et al. (Neuron. 2005 Aug 4;47(3):365-78)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16055061&dopt=Citation

Google "synaptic mitochondria for more"

As to dendrites, there can be mitochondria there, too.  See "The
importance of dendritic mitochondria in the morphogenesis and
plasticity of spines and synapses" by Z Li et al. (Cell 2004, vol.
119, no6, pp. 873-887)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15607982&dopt=Abstract&holding=f1000,f1000m,isrctn

As to how the mitochondria get where they are supposed to go, look at
"Nerve Cells' Power Plants Caught In A Traffic Jam "
http://www.physorg.com/news5610.html







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