Int J Dev Neurosci. 2006 Jun 12; [Epub ahead of print]
Dehydroepiandrosterone (DHEA) treatment stimulates oxidative energy
metabolism in the cerebral mitochondria from developing rats.
Patel MA, Katyare SS.
Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao
University of Baroda, Vadodara, Gujarat 390002, India.
Effects of treatment with dehydroepiandrosterone (DHEA) (0.2 or 1.0mg/kg
body weight for 7 days) on oxidative energy metabolism in cerebral
mitochondria from developing and young adult rats were examined. Treatment
with DHEA did not change the body weight of developing rats but resulted in
increase in the brain weight in 5 week group. In young adult rats the body
weight increased following treatment with 1.0mg DHEA. State 3 and state 4
respiration rates with all the substrates increased following DHEA
treatment, the effect being more pronounced in the developing rats. State 4
respiration rates were stimulated to variable extents. Contents of
cytochromes aa(3) and b increased following DHEA treatment and once again
the effect was more pronounced in the developing rats. DHEA treatment
marginally changed the content of cytochromes c+c(1.) In the developing
rats the ATPase activity and the levels of dehydrogenases increased
significantly by DHEA treatment. Results of our studies have shown that
treatment with exogenous DHEA accelerates the process of maturation of
cerebral mitochondria thus emphasizing the role of DHEA in brain
development in postnatal life.