Dear Peter and Petra:
How nice it is to realize that some ideas are indeed in the air!
I've read your comments with intense interest. Only a postgrad, I would only
comment on the following:
- a number of people have looked at the trauma issue in dementia, AD-type.
Some ruled it out completely. Some are still wondering. Those who have ruled
it out , I think, used the so called PTSD symptom screening measures. I
think the behavioral measures have only so much ability to discern. There is
a need for a neurobiological marker, i.e. a combined neuropsych/neuroimaging
pattern. I think the absence of this, on one hand, and
- the barrier between two or more qualitatively different types of
investigation (watching metabolic correlates, but not…say, information
processing type) is another problem preventing for finding an answer sooner.
In short, there is a need for a COMPREHENSIVE, i.e. methodologically
COMPLETE type of studies which is… hard to come by.
Aside from these, I am fully supporting Peter's view on pathogenesis of
dementia, AD-type, i.e. in relation to the Trauma-factor. When it comes to
the brain regions involved, I am afraid until we understand tghe information
processing in general, there will be a huge methodological problem to
identify what's happening under the influence of a super-trauma and the
sequella born by it.
However, unless there is an approach which investigates the PROCESS of the
illness, starting with a comprehensive investigation of the onset symptoms,
especially with NSS – neurological soft signs, moving onto identification of
the sequella of the brain regions involved, then interpreting the
consequentially induced information processing deficits/disruptions, and
then considering the appearance of the stable metabolic and biochemical
changes, would be a way to go. So far… it's just bits and pieces…
so, having only the background in clin psych and a bit of related
experience, could I ask you, guys, to send me the info on both the described
evidence of the traumatic experience as well as on oxidative cell stress?
all the best, as well ,thanks for the Love, Petra
Cheers,
Konstantin
>From: "Petra" <petra.proeglhoef at onemail.at>
>To: neur-sci at magpie.bio.indiana.edu>Subject: [Neuroscience] Re: entorhinal cortex
>Date: 24 Feb 2006 02:53:00 -0800
>>Hi!
>>I'm sorry that my english is not so good (I can speak very well but am
>not very much into scientific english, but I learn...). But as far as I
>understood, you think that supressed conflicts or traumata are
>responsable for the onset of Alzheimer? That's an interesting thought.
>There are some hypotheses about oxidative cell stress...
>>The entorhinal cortex is the first place where plaques appear, then the
>plaques destroy the whole limbic system and at the end the isocortex is
>affected. This happens in every brain, systematically. We know that,
>but we don't know why the plaques appear. There are no biomarkers.
>>LOve Petra
>>>Peter F wrote:
> > "Petra" <petra.proeglhoef at onemail.at> wrote in message
> > news:1140541502.167858.128800 at o13g2000cwo.googlegroups.com...> > > Hi everybody!
> > >
> > > Has somebody read any articles about the relationship between damage
> > of
> > > the entorhinal cortex and Alzheimer's disease? I'm trying to work on
> > > that topic and find it very difficult to find/get informations.
> >
> > [Sorry for not saying anything other than that some
> > googling might satisfying your appetite for information.]
> >
> > I am seeing that there is an opportunity to
> > connect (at least conceptually) this region of the cerebral cortex
> > with the by Radium (recent poster in this NG) indirectly
> > pointed out possibility of a conditioning for a reflexive and habitual
> > maintenance of a highly selective unconsciousness of certain
> > traumatically painful
> > (including emotionally or psychologically so) stored (or imprinted)
> > experiences.
> >
> > And, that such a staving off, of "conditioned-in" [and chronically kept
> > as if "hibernated" - i.e. specifically, not generally, so - but
> > unconsciously
> > remembered (or "reverberating") stressors -, and effecting symptoms
> > *nevertheless*] potentially self-defeatingly distressful
> > endogenous signals thus chronically caused by *no longer environmentally
> > current*
> > "specific hibernation imploring type (~traumatizing) situations",
> > can in combination with other factors (e.g. a chronically elevated
> > secretion of cortisol)
> > strongly contribute to the onset of Alzheimer's disease amongst many
> > other somatic
> > and psychological symptoms of 'dis_ease'.
> >
> > All this can be insight-inspiringly inserted (albeit by very few people)
> > within an entirely science-aligned rational and realistic philosophical
> > frame that can be expressed by "concEPTs" such as (e.g.):
> > (Our) AEVASIVE (neuropsychobiology); SHITS come CURSES,
> > and their frequent conflux with "opportunity type" evolutionary
> > pressures
> > (as part of the "Evolutionary Pressure Totality").
> >
> > All by me contrived concEPTs are mainly relevant to the phylogeny of
> > fauna;
> > and especially relevant to the phylogeny of folk.
> >
> > P
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