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diet soda sweetener aspartame [ NutraSweet, Equal, Canderel, E951, Benevia ] toxicity research: Murray 2004.10.11 rmforall

Rich Murray rmforall at att.net
Mon Oct 11 16:11:00 EST 2004

diet soda sweetener aspartame [ NutraSweet, Equal, Canderel, E951, Benevia ]
toxicity research: Murray 2004.10.11 rmforall

Rich Murray, MA    Room For All    rmforall at comcast.net
1943 Otowi Road, Santa Fe, New Mexico 87505 USA  505-501-2298
http://groups.yahoo.com/group/aspartameNM/messages     Moderator
139 members,  1,121 posts in a public searchable archive

Fully 11% of aspartame is methanol [ wood alcohol ] --  1,120 mg aspartame
in 2 L diet soda, almost six 12-oz cans,  gives 123 mg methanol (wood
alcohol) -- the same amount that produces hangover from red wine.

The methanol is  immediately released into the body after drinking -- 
unlike the large levels of methanol locked up in complex molecules inside
many fruits and vegetables.

Within hours, the body turns much of the methanol into formaldehyde, and
then much of that into formic acid, both of which in time are partially
eliminated as carbon dioxide and water.

This long-term low-level chronic toxic exposure leads to typical patterns of
increasingly severe complex symptoms, starting with headache, fatigue, joint
pain, irritability, memory loss, rashes, and leading to vision and eye
problems, and even seizures. In many cases there is addiction.  Probably
there are immune system disorders, with a hypersensitivity to these toxins
and other chemicals.

Many scientific studies and case histories report:  * headaches  * many body
and joint pains (or burning, tingling, tremors, twitching, spasms, cramps,
stiffness, numbness, difficulty swallowing)  *  fever, fatigue, swollen
glands  * "mind fog", "feel unreal", poor memory, confusion, anxiety,
irritability, depression, mania, insomnia, dizziness, slurred speech, sexual
problems,  poor vision, hearing (deafness, tinnitus), or taste  * red face,
itching, rashes, allergic dermatitis, hair loss, burning eyes or throat, dry
eyes or mouth, mouth sores, burning tongue  * obesity, bloating, edema,
anorexia, poor appetite or excessive hunger or thirst    * breathing
problems, shortness of breath * nausea, diarrhea or constipation  * coldness
* sweating  * racing heart, low or high blood pressure, erratic blood sugar
levels  * hypothryroidism or hyperthyroidism  * seizures  * birth defects
* brain cancers  * addiction  * aggrivates diabetes, autism, allergies,
lupus, ADHD, fibromyalgia, chronic fatigue syndrome, multiple chemical
sensitivity, multiple sclerosis, pseudotumor cerebri and interstitial
cystitis (bladder pain).

Aspartame and its effects on health, Michael E.J. Lean, Catherine R. Hankey,
Glasgow UK, British Medical Journal: 11% methanol component of aspartame,
and same level of methanol in dark wines and liquors, turns to formaldehyde
and formic acid, the main cause of chronic hangover symptoms: Murray
2004.10.04 rmforall

5 critical Rapid Responses to Aspartame and its effects on health, Michael E
J Lean and Catherine R Hankey, BMJ 2004; 329: 755-756: Murray 2004.10.07
rmforall   http://bmj.bmjjournals.com/cgi/eletters/329/7469/755#76712

Formaldehyde, an acknowledged human carcinogen, which is prevalent in
modern society, is a largely unacknowledged co-factor that must impact many
of the studies based on the Nurses Health Study.

One major source is the methanol impurity,  about one part in ten thousand,
in dark wines and liquors, which is converted by the body into formaldehyde
and then formic acid, both potent, cumulative toxins that affect every
tissue, and are seen by experts as the main cause of the infamous "morning
after" hangover.

"Many pathophysiological disturbances occur during hangover, including
dehydration;  metabolic acidosis;  hypoglycaemia;  disturbed prostaglandin
synthesis;  abnormal secretion of vasopressin,  cortisol,  aldosterone,
renin,  and testosterone;  increased cardiac output;  tachycardia;  and

http://bmj.bmjjournals.com/search.dtl       search to get free full text
British Medical Journal 1997 (4 January); 314(7073): 2.
Ian Calder, F.R.C.A. [ Tel/Fax: 0171 720 9279   Consultant Anaesthetist at
the National Hospital for Neurology and Neurosurgery,
London  WCIN 3BG, UK ]

Editorials         Hangovers: Not the ethanol - perhaps the methanol

"Chapman found that hangover symptoms were almost twice as common in
volunteers who drank 1.5 ml/kg [ body weight ] of bourbon whiskey - which
has methanol concentrations of 26 mg/l - as in those drinking the same dose
of vodka ( 3.9 mg of methanol per litre ). (5)   [ For a 60 kg person, this
would be 90 mg bourbon, 0.09 l, giving 2.34 mg methanol, which led to twice
as many symptoms as the 0.35 mg methanol  from vodka.  The bourbon gave as
about as much methanol as an ounce of diet soda. ]

Pawan compared the hangover produced by different types of drink (but only
one brand of each) in his study of 20 volunteers. The severity of hangover
symptoms declined in the order of brandy, red wine, rum, whisky, white wine,
gin, vodka, and pure ethanol.(6)  Vodka and pure ethanol caused only mild
headaches in two volunteers.

Jones has suggested that it is the metabolism of methanol to formaldehyde
and formic acid that causes symptoms of hangover, with quicker methanol
metabolisers suffering more.(7)  The justification for this suggestion is
the types of drink associated with more severe hangovers contain higher
levels of methanol;
the time course of methanol metabolism corresponds to the onset of symptoms;
and a small dose of ethanol, which blocks the formation of formaldehyde and
formic acid, provides an effective treatment for hangovers ("the hair of the

Jones AW (1987) found next-morning hangover from red wine with
100 to 150 mg methanol
(9.5% w/v ethanol; 100 mg/l methanol =  0.01%, one part in ten thousand).

The expert review by Monte WC (1984) states:  "An alcoholic consuming 1500
calories a day from alcoholic sources alone may consume between 0 and 600 mg
of methanol each day depending on his choice of beverages (Table 1)...."
Table 1 lists red wine as having 128 mg/l methanol, about one part in ten

Fully 11% of aspartame is methanol --  1,120 mg aspartame  in 2 L diet soda,
almost six 12-oz cans,  gives 123 mg methanol (wood alcohol) --  the same
amount that produces hangover from red wine.

"Between a quarter and a half of drinkers claim not to experience hangover
symptoms despite having been intoxicated. (three citations)"   This
indicates a remarkable range of individual vulnerability to formaldehyde and
formic acid exposure.

Other strong formaldehyde sources are tobacco and wood smoke, and the
particleboard and new furniture, carpet, and drapes especially concentrated
in mobile homes.  Many personal care products contain formaldehyde; for
instance, leather shoes can cause foot dermatitis.

Similar  levels of methanol, and its inevitable products in the human body,
formaldehyde and formic acid, can also ensue from fermentation of fruit
pectins in the colon.

Poor memory is one of the main early complaints of aspartame reactors, who
are often people who use over 6 cans ( 2 L) diet soda daily for years.

The 6 experimental rats in this recent economical, focused pilot study by
McConnaughey M et al (2004 May), drank a comparable level for 4 months,
about 13% of a 30-month lifespan.  It is an excellent introduction to the
main issues.

Only after 3 months did the 6 aspartame rats show almost a doubling of time
to run a single-choice maze.

At 4 months, there was almost another doubling of delay:  "...two of the
treated rats even went to the wrong side of the T-maze, totally forgetting
where the reward was."   These are very powerful, worrisome results.

There were highly significant, neurologically relevant changes in certain
brain receptor densities, and changes in brain chemistry.

With 70 citations, the relevant scientific literature is well summarized.
Many other studies, often industry funded, often used single doses or
too short durations of exposure, along with lower doses, thus rarely proving
memory deficits.

The funding source for this extremely valuable study is not given.
It used a team of talented high school students.

The fact that certain brain receptor densitities increased, and that memory
deficit increase took 3 months to be significant, may reflect the paradox of
hormesis, the complex ability of organisms to make themselves stronger in
response to low levels of toxins:

Murray, full plain text & critique:
chronic aspartame in rats affects memory, brain cholinergic receptors, and
brain chemistry, Christian B, McConnaughey M et al, 2004 May:
2004.06.05 rmforall

Pharmacol Biochem Behav. 2004 May; 78(1): 121-7.
Chronic aspartame affects T-maze performance, brain cholinergic receptors
and Na(+),K(+)-ATPase in rats.
Christian B, McConnaughey K, Bethea E, Brantley S, Coffey A, Hammond L,
Harrell S, Metcalf K, Muehlenbein D, Spruill W, Brinson L, McConnaughey M.
Department of Pharmacology, Brody School of Medicine, East Carolina
University, Greenville, NC 27858, USA;
North Carolina School of Science and Mathematics, Durham, NC 27811.
Mona M. McConnaughey, Ph.D.  Research Assistant Professor
Office: Brody Medical Science 6E-120A    252-744-2756
MCCONNAUGHEYM at mail.ecu.edu

This study demonstrated that chronic aspartame consumption in rats can lead
to altered T-maze performance and increased muscarinic cholinergic receptor
densities in certain brain regions.
Control and treated rats were trained in a T-maze to a particular side and
then periodically tested to see how well they retained the learned response.
Rats that had received aspartame (250 mg/kg/day) in the drinking water for 3
or 4 months showed a significant increase in time to reach the reward in the
T-maze, suggesting a possible effect on memory due to the artificial
sweetener.  Using [(3)H]quinuclidinyl benzilate (QNB) (1 nM) to label
muscarinic cholinergic receptors and atropine (10(-6) M) to determine
nonspecific binding in whole-brain preparations,
aspartame-treated rats showed a 31% increase in receptor numbers when
compared to controls.
In aspartame-treated rats, there was a significant increase in muscarinic
receptor densities in the frontal cortex, midcortex, posterior cortex,
hippocampus, hypothalamus and cerebellum of  80%,  60%,  61%,  65%,
66%  and 60%, respectively.
The midbrain was the only area where preparations from aspartame-treated
rats showed a significant increase in Na(+),K(+)-ATPase activity.
It can be concluded from these data that long-term consumption of aspartame
can affect T-maze performance in rats and alter receptor densities or
enzymes in brain.  PMID: 15159141

The moderated newsgroup, bionet.toxicology , has accepted 19 of my long
reviews since March 24:

Dr. Charles "Chuck" A. Miller III   rellim at tulane.edu
Associate Professor of Environmental Health Sciences
374 Johnston Building, SL29
Tulane Univ. School of Public Health and Tropical Medicine
1430 Tulane Avenue  New Orleans, LA 70112   (504)585-6942
Bionet.toxicology news group http://www.bio.net/hypermail/toxicol/current

safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF:
Murray 2003.01.12 rmforall  EU Scientific Committee on Food, a whitewash

Mark Gold exhaustively critiques European Commission Scientific
Committee on Food re aspartame ( 2002.12.04 ): 59 pages, 230 references

http://www.HolisticMed.com/aspartame    mgold at holisticmed.com
Aspartame Toxicity Information Center    Mark D. Gold
12 East Side Drive #2-18 Concord, NH 03301     603-225-2110
"Scientific Abuse in Aspartame Research"

841 members, 17,441 posts in a public, searchable archive
http://groups.yahoo.com/group/aspartame/messages    bryanth at brooksdata.net
Aspartame Victims Support Group    Edward Bryant Holman, Chief Moderator
836 members, 17,489 posts in a public, searchable archive

http://www.HolisticMed.com/aspartame    mgold at holisticmed.com
Aspartame Toxicity Information Center    Mark D. Gold     also Co-Moderator
12 East Side Drive #2-18 Concord, NH 03301     603-225-2110
"Scientific Abuse in Aspartame Research"

http://google.com  gives 245,000 websites for "aspartame" , with the top
7 of 10 listings being anti-aspartame, while
http://groups.google.com  finds on 700 MB of posts from 20 years of
Usenet groups, 99,700 posts, the top 10 being anti-aspartame.
http://news.google.com   recent aspartame items from 4500 sources.
http://www.ncbi.nlm.nih.gov/PubMed   lists 769 aspartame items.

corporate crime in aspartame toxicity research: President Bush and John
Edwards both victims: has Al Gore quit it?: William Thomas: Murray

2004.09.23 Hello Will,       http://www.willthomas.net/Contact/index.htm

Jill Lawrence and Judy Keen reported in USA Today 2004.09.22 page 1:
Cover story: Election is turning into a duel of the manly men:
It's more than posturing: Image may win key states.

""Bush, who uses a treadmill on Air Force One during long trips, is the
first presidential candidate to run ads in health clubs.

He was once an avid runner, but aging knees put an end to that.

Now he works out aboard a mountain bike.
He loves to fish, and he hunts and golfs occasionally."

Joint pain, especially in the knees, are among the major complaints with
chronic aspartame (methanol, formaldehyde, formic acid) toxicity.

In The New Yorker 2004.09.13 pages 56-71, David Remnick in
PROFILES   The Wilderness Campaign    Al Gore, four years later,
describes Al and Tipper drinking coffee, tea, and alcohol, but no Diet Coke,
at several meals.

In the 2000 campaign, there were were many stories describing him drinking
as much as 6 Diet Cokes daily.

Can you check this out?  If he has quit it, and is finding much improved
health, that gives an unusual opportunity to spotlight at a crucial juncture
yet another serious failure in the Bush administration and to help many
unaware victims by making discussion of this contentious issue legitimate.

Let me know if I can help in any way.  You may utilize anything I have ever

In mutual service,  Rich Murray

Rich Murray, MA    Room For All    rmforall at comcast.net
1943 Otowi Road, Santa Fe, New Mexico 87505 USA  505-501-2298


Judge Orders U.S. to Find Bush Records     Thursday, 16-Sep-2004 7:30 PM
Story from AP / MATT KELLEY, Associated Press Writer
Copyright 2004 by The Associated Press (via ClariNet)

16-SEP-2004: Tara Morrissey, left, who works the counter at Brick House
Deli, reacts as President Bush, right, buys a diet soda in Anoka, Minn.,
during an unscheduled stop during a campaign bus tour Thursday, Sept. 16,
2004. (AP Photo/Charles Dharapak)  [Photo copyright 2004 by AP]

review of sweeteners 2004, Weihrauch MR, Diehl V: formaldehyde from 11%
methanol component of aspartame, methanol in dark wines and liquors,
fermentation of fruits in colon, also smoke, new buildings, furniture,
drapes, carpets, personal products: available database from Harvard Nurses'
Health Study II of  91,249 women in 1991-1999: Murray 2004.09.18 rmforall

A very detailed, highly credible account of the dubious approval process for
aspartame in July, 1981 is part of the just released two-hour documentary
"Sweet Misery,  A Poisoned World:  An Industry Case Study of a Food Supply
In Crisis" by Cori Brackett:   cori at soundandfuryproductions.com
http://www.soundandfuryproductions.com/  520-624-9710
2301 East Broadway, Suite 111  Tucson, AZ 85719

Donald Rumsfeld, 1977 head of Searle Corp., got aspartame FDA approval:
Turner: Murray 2002.12.23 rmforall

President Bush & formaldehyde (aspartame) toxicity: Ramazzini Foundation
carcinogenicity results Dec 2002: Soffritti: Murray 2003.08.03 rmforall

re "dry drunk": Bisbort: danger to President Bush from aspartame toxicity:
Murray: 2002.02.24   2002.09.29 rmforall

Is Bush Nuts?: William Thomas willthomas.net  2004

politicians and celebrities hooked on diet sodas (aspartame):
Murray 2004.03.24 rmforall

John Edwards gives up Diet Coke: The Cult of Diet Coke, Eric Gillin:
Murray 2004.07.12 rmforall

John Edwards still drinks Diet Coke (aspartame): TIME Europe  July 19 issue:
Murray 2004.07.12 rmforall

hyperthyroidism (Graves disease) in George and Barbara Bush, 1991--
aspartame toxicity?  Roberts 1997: Murray 2002.10.09 rmforall

aspartame expose 96K Oct 1987 Part 1/3: Gregory Gordon, UPI reporter:
Murray 2000.07.10 rmforall

aspartame history Part 1/4 1964-1976: Gold: Murray 1999.11.06  rmforall

revolving door, Monsanto, FDA, EPA: NGIN: Murray 2002.12.23 rmforall

RTM: Merisant Co., MSD Capital, Dell Computer Corp., NutraSweet Co.,
JW Childs Assc.: aspartame-neotame toxicity 2002.07.10 rmforall

www.dorway.com: original documents and long reviews of flaws in
aspartame toxicity research: Murray 2002.07.31 rmforall

Samuels: Strong: Roberts: Gold:  flaws in double-blind studies re
aspartame and MSG toxicity: Murray 2002.08.01 rmforall

http://www.truthinlabeling.org/    Truth in Labeling Campaign [MSG]
Adrienne Samuels, PhD   The toxicity/safety of processed
free glutamic acid (MSG): a study in suppression of information.
Accountability in Research 1999;  6:  259-310.  52-page review
P.O. Box 2532 Darien, Illinois 60561
858-481-9333   adandjack at aol.com

Rich Murray, MA    Room For All    rmforall at comcast.net
1943 Otowi Road, Santa Fe, New Mexico 87505 USA  505-501-2298

139 members,  1,121 posts in a public searchable archive

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