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what is down-regulation?

Dr. Andrew B. Chung, MD/PhD andrew at heartmdphd.com
Thu Jan 29 10:02:57 EST 2004

jjones at bone.net wrote:

> what does down regulation mean in the context of the glucocorticoid
> receptors in the hypothalamic pituitary axis in response to low cotisol
> levels (like in the event of PTSD)?

The expression of the gene for the glucocorticoid receptor may be dialed

This means less mRNA for this gene which means less receptors.

> thanks.

You are welcome.



Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist

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