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A Theory of Neuropeptides?

Peter F. effectivespamblock at ozemail.com.au
Tue Jan 20 23:36:48 EST 2004


"yan king yin" <y.k.y at lycos.com> wrote in message
news:72de81ae.0401200008.4b051a4e at posting.google.com...
> "Peter F." <effectivespamblock at ozemail.com.au>
>
> > It is in *every way* plausible (i.e., not just because it has been
> > experimentally
> > evidenced) that some *key* type glutaminergic neurons ("key" in respect
of
> > what I am about to suggest - or perhaps rather assert and conclude),
*can*
> > start
> > to release substance-P at a 'certain' treshold of excitatory (at least
> > potentially directly distress, or flight, motivating) firing, AND at
some
> > still higher frequency (or same frequency but longer duration?) some
opioid
> > type neuromodulator.
>
> I'm not sure where your references are... but I just looked up some
> evidence that pyramidal neurons may co-release peptides along with
> glutamate. This may support the hypothesis that neuromodulation by
> neuropeptides subserves an "information-overflow" mechanism. The
> papers are kind of old, 1992-3.
>

Good of you to supply references!

However, there exist so many more scientific clues and evidence - *of all
kinds* - that we would need Parkinson's disease to keep sitting on our hands
instead of going on to usefully unifyingly grasp and understand what is
going on in respect of how and why we (and other similarly brainy animals)
are how we are!

Best wishes,

P





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