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Applying Statistical Methods to Neuron Modeling

Michael Olea oleaj at sbcglobal.net
Tue Jan 20 10:36:57 EST 2004

in article 72de81ae.0401200109.4eecb31c at posting.google.com, yan king yin at
y.k.y at lycos.com wrote on 1/20/04 1:09 AM:

> I think it's possible to apply statistical methods
> to highly realistic single-neuron models (such as
> NEURON or GENESIS) and thus automatically obtain
> *simplified* single-neuron models. The statistical
> methods include:
> 1. dimensionality reduction
> 2. nonlinear regression
> and a plethora of tools I've just discovered from
> books recently. If this is possible, then we can
> start to talk about dendritic integration in
> quantitative terms, with the simplified equations.
> Has anyone done this?

See "Spikes: Exploring The Neural Code" by Rieke, Warland, de Ruyter van
Steveninck, and Bialek. MIT Press. 1997.

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