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Synaptic communication and re-uptake / reuptake inhibitors / Adrafinil

1234 123412 at 101.com
Thu Dec 16 17:14:03 EST 2004

>>Also how could things like Adrafinil (norepinephrine agonist) work? Is 
>>it stored in vesicules at the end of axons together with the 
>>norepinephrine and released into the synapses together with it?
> [...]
> Not stored.  Diffusion.  Diffusion. OK?

Explain "diffusion" to a layman please?

Does it leak out of the brain vessels and spreads into all the synaptic 
clefts roughly equally? (I don't know how this could be helpful: seems 
to add just random "noise" to brain signals...?)

...and then is it reabsorbed in the vessels when the concentration of 
the agonist in the vessel becomes lower (liver has worked) than the 
concentration in the synaptic clefts?


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