IUBio

question related to EPSC/EPSP

Xiaoshen Li xli6 at gmu.edu
Thu Dec 25 20:00:29 EST 2003


Hi Everybody:

I am confused with EPSP and EPSC(Excitatory Post Synaptic 
Potential/Current). Specifically:

I saw a formula to describe an excitatory synapse stimulation effect: i 
= G * (v-e); G = weight * exp(-t/tau); i(nA synaptic current), 
G(microSiemns synaptic conductance), e(mV reversal potential), tau(mS 
decay time constant), weight(synaptic weight), v(mV membrane potential).

Since e is constant, so i is determined by G and v. G is keeping 
chaning: G decays with tau; I think v is keep changing due to the inflow 
i, am I right? So i does not decay with a single time constant, am I 
right? What i trace will looks like?

If weight is increased, i will be increased. How about EPSP? Will it be 
increased too?

Maybe some questions are not reasonable. But you can see I am very 
confused. Thank you very much for your help. I greatly appreciate it.

Best Regards,
Xiaoshen




More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net